Newly rescues an ignorant hill girl, Merry Florene from her uncivilized half-brothers, Roland and Elbert. He brings her to Dodge City and arranges for a job at Jonas' general store. The two ruffians find her and try to force her to help them rob the store.
Jubal Gray (Jim Davis) and his gang of renegade ex-soldiers steal a cache of rifles and gunpowder to sell to a band of marauding Indians. In a chance encounter they seriously injure Tahrohon (Dan Ferrone), an Indian friend of buffalo-man Noah Meek (Michael Constantine). Noah vows revenge for his friend's wounds.
Matt goes to Texas to attend the retirement party of his old friend, Sheriff Mark Handlin. After witnessing his friend's assassination by five desperadoes whom Mark had previously sent to prison, Matt chases them into Mexico.
With a drought around Dodge, a city slicker named Norm Trainer plans on profiting off the local farmers. The only hope the farmer have is a 'water-witch' named Sam'l. But everyone is not happy with Sam's presence in Dodge.
Matt pursues the Rawlins gang into Mexico to the village of Zavala. Here he meets Paco and his widowed mother. Paco's father had been killed when he stood up to outlaws intimidating the people of Zavala. In his whole life, the only strong willed people Paco had ever seen were outlaws. He first thinks of Matt as such a person, until Matt tells him that he not here to kill the Rawlins' but to arrest them. "But only outlaws ever come to Zavala." Paco is fascinated with the fact that Matt is a US Marshall. In an unusual episode of Gunsmoke an unlikely relationship ...
Will Geer plays an old mountain hunter that comes to Dodge to see his long time friend Matt Dillon. When the hunter is accused of attempted murder, it will be Matt that sets off to bring his friend to justice.
The Ward gang is on the run after a bank robbery. The gang loses one of the Ward brothers, shot in the stomach, while Abelia and another gang member go to Dodge for a painkiller. While in town Festus and Newly have a run-in with the pair. Festus has a tracking job which leads him to Abelia's home where the gang has already taken off south bound. One of Abelia's children is bitten by a snake and Festus stays on to help heal the girl.
On the way back to Dodge with outlaw Waco Thompson, Matt runs into a very pregnant Indian woman. With a gang on their heels Matt finds a farm house to help the woman, but runs into bigotry with a painful past.
Johnny Cross, though innocent, is a wanted man. Bounty hunters are after the reward. Newly finds him and intends to bring him in. Johnny has a choice to make when Newly is injured on the way back to Dodge.
Down on his luck, a widowed farmer is unable to get a loan from his brother-in-law, a banker in Dodge City. The two briefly argue. The farmer's son and daughter, however, go back to the bank, cause a commotion and steal an envelope full of money. Marshal Matt Dillon is out of town, leaving Festus in charge of investigating the incident. The farmer is arrested for the robbery. Upon hearing from his children that they took the money, he forbids them from telling the law; he feels he'll only be using his children as scapegoats. A short time later, the children run away ...