While foiling a stage holdup Dillon takes one of the men prisoner. While bringing him back to Dodge he must deal with the prisoner's brother and his gang and their attempts to free him. Things become more complicated when Newly is taken prisoner.
Josh Stryker, a former U. S. Marshal, returns to Dodge City after fifteen years in prison for murder. His former deputy, Matt Dillon was the main witness who convicted him. Now Stryker is torn between his hatred for Matt, his reconciliation with his daughter Sarah Jean, and the threat he faces from two outlaws, Jessup and Reager.
Marshal Matt Dillon is brought to Coreyville by Ellie Wylie to ensure a fair trial for her brother, Titus. In the process Matt must deal with the town matriarch, Agatha Corey and her sons Billy Joe and Frank. Flo Watson, the redheaded saloon keeper, plays a prominent part in the intrigue.
Outlaw Will Smith visits his ex-wife Abelia so she can fence some stolen gold in order for him to escape into Mexico. Festus becomes suspicious when he sees Abelia in a seedy establishment late at night.
Matt Dillon is escorting his prisoner Charlie Noon back to Dodge City when he encounters a runaway Indian bride being pursued by the braves of her tribe. The Indians have mistaken Charlie Noon as the man who stole her and are seeking revenge. The suspense builds in this episode as all parties are seen to match wits and maneuver for strategic advantage rather than employ violence. "Charlie Noon" is thus noted more for intrigue than the activity one would expect of a typical western.
Ben Hurley, a poor farmer, steals horses for outlaws to get enough money to take his blind daughter Susan to Kansas City, where she can learn to read and lead a better life. Newly tries to find the rustlers and becomes involved in the young girl's plight.
After twenty years in prison, Jake MacGraw comes to Dodge City to start over. He takes a job as piano player at the Long Branch, but is this really why he came to town? He woos one of the saloon girls and seems to want a fight with her beau. What's that all about?
The Sadlers have scraped and saved all their lives to have a home. When they finally move into one, the bank that has all their money closes and the previous owner of their home wants an immediate payoff. Not able to meet his demand they decide to take matters in their own hands.
An Indian warrior, Gregorio is wounded escaping from the U.S. Army Fourth Cavalry, and the bigoted, ruthless Sgt. Emmet Holly sets out in hot pursuit. Gregorio encounters Kitty Russell, steals her horse and takes her hostage. Meanwhile, Marshal Matt Dillon is tracking all of them.
As Matt escorts a wounded prisoner to Ft. Union, his camp is invaded by a thieving young boy, whom Matt takes into custody. In Dodge City the journey to Ft. Union is joined by two women, one pregnant traveling to see her husband, the other secretly the wife of the prisoner. A trio of outlaws waits on the trail to kill Matt and rescue the prisoner.
Matt is seriously wounded in a gun fight. Kitty is so despondent, she puts up the Longbranch for sale, bids Matt goodbye and leaves Dodge City. In a new town, in another saloon she finds out why Matt is the kind of man he is.
Albert Schiller (Milton Selzer) is losing his job as teller at the bank. When outlaws led by Jake Spence (William Schallert) are unsuccessful in robbing the bank, Albert takes $5,000 and blames it on the gang. Irate at the wrongful accusation, the robbers return and force Albert to join them by taking his wife Kate (Patricia Barry) prisoner. Worst of all, she is menaced by the sociopathic Nix (L. Q. Jones).
Long Branch bartender Sam Noonan reveals a good bit about his young life while talking to a young man on probation for theft. The thieves, all teenagers, have been given a 'work release': two of them work on a farm and the third for the Long Branch Saloon as Sam's helper. They chafe under the heavy-handed supervision of a small-time lawman who watches over them and takes every opportunity to make their lives miserable. Sam, himself an ex-con from way back, helps out the kid as a sort of payback to a mentor who helped him when he got into trouble. One of the other two,...
Will Hackett has just been released from prison after serving ten years for a foiled train robbery. Hackett just so happens visits the farm of Quentin Sargent, a former partner that ran out on him during the robbery.