A man is convicted of robbing and murdering his partner, but the sons of Matt's old friend are responsible. Matt must arrest the remaining son after the other's dying declaration and make it to Hays City in time to stop the hanging.
An elder brother took the blame for the younger as both were sent away for cattle rustling. When they return home, the younger is not done with doing wrong, nor with asking his brother to cover his tracks.
Twenty-two men escape from a territorial prison. The remaining 4 kidnap Matt hoping to get safe passage into Mexico. One of them has another agenda which he reveals to Matt as they get closer to the border.
After a risky train robbery and with two posses on their trail, four men hurriedly ride to some fresh horses. Dillon wounds one of the gang carrying the stolen money and it turns out to be a young woman.
A retired judge and his sons abduct Kitty, Festus, and Doc after Festus shoots his other son in order to defend Kitty. The judge "tries" Kitty and Festus for murder, pressing Doc into service as their defense attorney.
When one of the gang is hurt after robbing Dodge, the Doc is taken to patch him up. The posse was preparing to go after them but a new problem has been set they must take care of before they can recover their friend.
In Matt's absence, Festus is accused of drawing first on a drunken man. Though innocent, Festus leaves town to avoid Matthew's having to arrest him, and takes refuge across the border with a widow and her son.
Festus has a habit of using the wishbone from a dead chicken for making wishes on. When he comes across the doc, alone and snakebit, he uses that wish to help him, if it can. Meanwhile, Matt searches for three outlaws who held up a stage, killing the driver and guard.
The Osage Council has found Two Bears guilty of murder. His daughter rides into Dodge seeking Matt's help but he's out of town chasing horse thieves so Thad tries to help. He finds out that he and Matt are really riding the same trail.
Some homesteaders have chosen a piece of land that is free to use per the government but Ben Payson has other ideas. When his daughter starts to care more about their son, he decides to force them off the property regardless the cost.
When old Jacob is shot dead in self defense, his loyal Indian partner, John Walking Fox, starts paying for things with $50 gold pieces, and he becomes the talk of the town, and a target for would be robbers.
A mysterious man rides into town and says he is after one of two men responsible for killing his brother. When he starts crowding a stranger in town, Matt must decide how to make sure he doesn't take the law into his own hands.