Cheyenne is deputized to look for six missing men. He finds more than he bargained for when he meets the Durango family and their strong desire to marry off the youngest in their family -- Lottie.
Sam is a friend to everyone in town. When offering to help little Billy who has a crippled leg, he works night and day in Eli's shop to create a miracle for the boy. But is he working feverishly on that or something else.
Cheyenne finds a boy unconscious on the trail who can't remember who he is. As he helps him regain his memory, he might have to watch out as he may have been involved in a killing and holdup.
At Jud Ainsley's murder trial, evidence turns up that discredits lawman Harry Thomas' testimony, and in fact Thomas is arrested and charged with robbery. However, after a mysterious gang attacks the van taking Thomas to prison, Cheyenne begins to suspect that Thomas was, as he claimed, framed.
Two gold prospectors see a Sioux warrior bringing two sacks of gold into town. They start searching all over the Sioux reservation, hoping to locate the mine the gold came from, in violation of a treaty. The local sheriff asks Cheyenne's help in keeping the incident from breaking out into an Indian war.
Cheyenne scouts for a railroad to lay track to the West. Where the track goes may not be up to the company paying for the route as someone else has a better one.
Conserving the dwindling buffalo is a heated debate in Washington. Cheyenne decides to step into recently vacated shoes and becomes a Senator. When drawing up the bill, he finds he has a lot of lessons in politics to learn; one of them his own impeachment!
Johnny is an Indian scout who escorts a widow to the stage in Globe. They are given safe passage through Indian burial grounds by Chief Chato but only Johnny believes it is a trap that may lead to all their deaths.
Cheyenne rides into town smack dab into an age-old range war - cattle vs. sheep. He attempts to dispel an old myth that the two can't graze together. His opposition: the whole town.