Sam is a friend to everyone in town. When offering to help little Billy who has a crippled leg, he works night and day in Eli's shop to create a miracle for the boy. But is he working feverishly on that or something else.
At Jud Ainsley's murder trial, evidence turns up that discredits lawman Harry Thomas' testimony, and in fact Thomas is arrested and charged with robbery. However, after a mysterious gang attacks the van taking Thomas to prison, Cheyenne begins to suspect that Thomas was, as he claimed, framed.
Two gold prospectors see a Sioux warrior bringing two sacks of gold into town. They start searching all over the Sioux reservation, hoping to locate the mine the gold came from, in violation of a treaty. The local sheriff asks Cheyenne's help in keeping the incident from breaking out into an Indian war.
Conserving the dwindling buffalo is a heated debate in Washington. Cheyenne decides to step into recently vacated shoes and becomes a Senator. When drawing up the bill, he finds he has a lot of lessons in politics to learn; one of them his own impeachment!
Johnny is an Indian scout who escorts a widow to the stage in Globe. They are given safe passage through Indian burial grounds by Chief Chato but only Johnny believes it is a trap that may lead to all their deaths.