Cisco and Pancho are asked by Marshal Ben Lane to track down a gang of counterfeiters in Durado. Cisco suspects the local banker and his clerk to be involved in the counterfeit, but cannot prove anything. He sets some traps for the gang. One of the traps involves arresting Pancho as an alleged bank robber.
Joe Dawson, foreman at a ranch in San Saba, asks his old friend Cisco to come and help them catch a gang of cattle rustlers. When the leader of the gang hears of this, he orders two of his henchmen to kill Joe and blame the murder on Cisco. Cisco and Pancho have to keep away from the sheriff at the same as they are searching for the gang and the missing cattle.
The Sheriff in Bonanza orders his assistant to bring the murderer Jim Hardy to the state prison, where Hardy is going to be hanged. On the way the assistant is killed by a shot from a man, who releases Hardy and brings him to his boss, Jim Holbrook. Holbrook plans to kill his employer, the ranch owner Henry P. Murdock, and replace him with Hardy, who resembles Murdock. Through this switch, Holbrook will get control over the ranch himself. The sheriff thinks that it is Cisco who has killed his assistant. Cisco and Pancho have to solve the whole mystery to prove that ...
Cisco and Pancho stumble across a ranch where the owner is arguing with a number of farm hands. It appears some of the cows have died from disease, and the rest will need to be quarantined. Cisco always happy to help a pretty lady, decides to get to the bottom of the issue.
Jasper King has asked his old friend Cisco to help him stop the marriage between his niece Nancy and the gangster Duke Ralston. Cisco and Pancho break the wedding ceremony and run away with the protesting bride. During a quarrel about this Duke kills Jasper. Nancy tells the sheriff that it is Cisco and Pancho who have killed her uncle. To prove their innocence Cisco and Pancho have to find the real murder and deliver him to the sheriff.
When a bank president is murdered, the townspeople accuse the man's future son-in-law of the crime and a lynching party is formed. Cisco and Pancho must find out who the real killers are before the mob hangs the innocent man.
Cisco and Pancho arrive in the town of Sundance. The town is in turmoil with a local thug 'Judd' trying to take over. After Cisco sees the destruction of a local newspaper office, he decides to hang around and sort things out.