Rowlf says that he fell in love with Lassie, but "she left me for Francis, the talking mule."
Moses's sons are watching one of the Francis movies at Moses's house one night.
Hawkeye says, "And in the movie version, the part of Charles Emerson Winchester III will be played by Francis, the talking mule."
Mentioned in In Search Of...
mentioned by Coach
referenced on Saturday Night News
Stu and the others watch a TV version of 'Francis' being shot at the TV station.
Crow: "Now, I'd like to ask Francis the Talking Mule a few questions."
When looking at the reviews of Ed's play, Ed refers to the fact that "Francis the Mule" had queues around the block despite bad reviews.
"You know this was Francis the Talking Mule's First Film"
"Phil the Talking Mule"
Francis the Talking Mule is mentioned in the 2003 film
When scanned, some of the humans mention Frances, the Talking Mule.
Fred compares Kelly's laugh to Francis'.
House calls a mule "Francis"
mentioned in dialogue
Mentioned in dialogue
"...giving us elements of Silence of the Lambs and Francis, the Talking Mule in one 45-minute episode."
Donald O'Connor is driving and singing while mule sings along.
Clip shown on a TV