The pairing of Irene Dunne and Cary Grant was a consistent box office winner and director H.C. Potter wanted Dunne for the role of Muriel Blandings. Unfortunately, she was already working on another RKO film, I Remember Mama (1948), and wasn't available for this production.
Although this film was from the novel of the same name, much of the story is autobiographical. Eric Hodgins and his wife built the actual house in the rural Litchfield County, Connecticut town of New Milford. Located in the bucolic Merryall section of town, the house recently sold for $1.2 million.
The house "Blandings' Way" really exists on Indian Hill Road in New Milford, Connecticut. It's a beautiful huge white art deco/colonial house that has many of the actual rooms discussed in the movie - such as a room to cut flowers. Also less than a mile away on Long Mountain Road is executive producer of the movie and MGM head Dore Schary's old country home.
In the movie, a flooded excavation plagues the Blandings and their builders, requiring pumps to empty it. In reality, Eric Hodgins reported in his interview with LIFE magazine that the movie set excavation leaked so badly that large pumps were required just to keep it filled for shooting.
Grand total for the house and property was $38,000 according to Mrs. Blandings in their first night in the house. Assuming the factor used to arrive at the 2010 value show above is correct, the total cost of the house and property would be $340,000.