Much of Cody's life as depicted in the film was true: He did fight to the death with Chief Yellow Hand and he did receive the Congressional Medal of Honor (although it was rescinded in 1917 because he was not in the army); his son, Kit Carson Cody, did die (but of scarlet fever, not diphtheria); his wife (not the daughter of a senator) had three other children.
Early production charts had Vincent Price in the role of "Murdo Carvell," but he was replaced by Frank Fenton when the role was severely cut. Many of the uncredited cast had more lines and screen time than Fenton, who was credited on screen.
Seen behind the opening and closing credits, the image of a Native American warrior on a horse is of a sculpture by American-born artist James Earle Fraser. The End of the Trail statue is located in Waupun, Wisconsin. It was added to the National Register of Historic Places in 1980.