In her final years at MGM, Joan Crawford was handed weak scripts in the hopes that she'd break her contract. Two films she hungered to appear in were Random Harvest (1942) and Madame Curie (1943). Both films went to bright new star Greer Garson instead, and Crawford left the studio soon after.
The trivia item below may give away important plot points.
The film makes no mention of the rather ironic fact that Marie Curie died of aplastic anemia at the age of 66, most likely because of her handling of radium in her lifetime. Her lab books are kept under lock and key as they are still irradiated more than 100 years after use.