Midwestern University is a thinly veiled reference to Thurber's own Alma Mater of The Ohio State University. There are numerous examples of OSU traditions in the film, including the singing of "We dont give a 'Darn' for the whole state of Michigan," notably Changing one word to appease censors. In addition, the team is called the Big Red Team, matching OSU's scarlet, and the marching band has uniforms that are identical to the uniforms still proudly worn by TBDBlTL (The Best Damn Band In The Land). 'The Big Game' featured in the film is against none other than OSU's biggest rival University of Michigan. Coincidentally, Osu Football won their first national championship in 1942, the year this film was released.
Don Defore created the role of "Wally Myers" in the original Broadway cast. When this movie was remade as the musical, "She's Working Her Way Through College," Defore took the role based on "Joe Ferguson."