
| John Wayne | ... | Larry Baker |
 | Shirley Grey | ... | Gloria Stratton, aka Gloria Martin |
 | Tully Marshall | ... | Howard L. Edwards, Railroad manager |
 | Conway Tearle | ... | Stevens, Railroad attorney |
 | J. Farrell MacDonald | ... | Jim Baker, Railroad engineer [Chs. 1, 5] |
 | Matthew Betz | ... | Tom Jordan, Railroad engineer (as Mathew Betz) |
 | James P. Burtis | ... | Det. Hemingway, Matthews, assistant (as James Burtis) |
 | Lloyd Whitlock | ... | Walter Gray, Airline manager |
 | Joseph W. Girard | ... | Detective Matthews (as Joseph Girard) |
 | Edmund Breese | ... | Frank Stratton, Gloria's father |
 | Al Bridge | ... | Carlson, Plainville station agent (as Alan Bridge) |
 | Ernie Adams | ... | Henchman Barney, Machine gunner (as Ernie S. Adams) |
 | Charles King | ... | Henchman Mike |
 | Glenn Strange | ... | Henchman Jim |
 | Al Ferguson | ... | Henchman Sandy - The 'Wrecker's' pilot |
| rest of cast listed alphabetically: |
 | Victor Adamson | ... | Baggage Master [Ch. 1] / Farmer [Ch. 3] / Train Passenger [Ch. 3] / Bob - the Station Master at Forsythe [Ch. 9] (uncredited) |
 | Yakima Canutt | ... | Henchman (uncredited) |
 | Henry Hall | ... | Doctor [Ch. 1] (uncredited) |
 | Rodney Hildebrand | ... | Bill - the Train Conductor [chs. 1, 2, 12] (uncredited) |
 | Eddie Parker | ... | Co-pilot [Chs. 1, 6] / Detective Nick [Ch. 9] / Doctor [Ch. 12] (uncredited) |
 | Fred Parker | ... | Plane Passenger [Ch. 1] (uncredited) |
 | Fred 'Snowflake' Toones | ... | Sam - the Train porter [Chs. 1,2, 3] (uncredited) |