This film is the first in the "Looney Tunes" series. Honey makes her first appearance. Bosko makes his first appearance in a theatrical film, and his second appearance of any kind. (His first appearance was in a demo reel called Bosko the Talk-Ink Kid (1929), which was never released commercially.)
The cartoon's opening credits originally had the legend "A Vitaphone song cartoon produced by Hugh Harman & Rudolph Ising", then changed to "A Hugh Harman-Rudolph Ising musical cartoon" and eventually to "A Hugh Harman-Rudolph Ising production".
The scenes in which Bosko's mouth fills the screen and he splits into miniature versions of himself were previously done in Bright Lights (1928), an Oswald the Rabbit cartoon that Hugh Harman and Rudolf Ising worked on whilst they were at Disney.
The first Looney Tune (complete with original titles), released in cinemas in May, 1930. Directed by Hugh Harman and Rudolf Ising, and featuring the voices of Carmen Maxwell as Bosko and Rochelle Hudson as Honey.