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- Enrique (Christopher De Leon), a compassionate doctor who does probo no work most of the time. But the character's innate generosity and close relationship with his patients have become a bone of contention between him and his family especially with his jealous wife. What happens if a man comes into conflict with his personal convictions, love for his family, and dedication to his medical practice?
- Dodong (Jiro Manio) and Nitoy (Carlo Aquino) are brothers who live without proper care and guidance from their parents. As a young boy, Dodong feels that he's different from his brother. He is gay. Despite the sexuality, his brother Nitoy, loves him so much. They've been through a lot in life especially when Nitoy loses sanity. To support his brother's medication, Dodong enters gay prostitution. He gets beaten up all the time by his customers but prostitution is the only way he knows how to survive and help Nitoy.
- The story of Margarita (Gretchen Barretto) forced to work off her sweat for her family while her good-for-nothing husband stays happily unemployed most of the time. Eventually though, she finds a good-paying job through the help of the town Mayor (Phillip Salvador) who becomes her good friend, and much later, her lover. Is it wrong for Margarita to fall for someone who can fulfill her needs for her family and as a woman? How can she stay faithful if the man she married does nothing but run away from his responsibilities?
- Mie-mie Barcelona (Mark Bautista) finds fulfillment in joining Ms. Gay pageants, where he always emerges as the winner. Like most homosexuals, he falls in love with a man, who eventually betrays him. As a form of revenge to his heartbreaking love affair with a man, Mie-mie undergoes a transformation-he dresses up and acts like a man. Eventually, he finds solace and falls in love with a woman who became the mother of his three kids. Later on, when his son falls seriously ill, Mie-mie is forced to join a gay beauty pageant, as his way of earning money immediately to save his son's life.
- As someone who comes from a very wealthy family, the life of Darlene ('K.C. Concepcion') practically evolves around boys, parties and all the luxuries in the world. Perhaps her attitude can't be helped since she's daddy's favorite girl. Everything she wants she gets with just a snap of her finger. All these changed however when her parents met a tragic accident, which claimed her father's life and rendered her mom paralyzed. Suddenly, she finds her family bankrupt and it's up to her now to support her ailing mother. Can she survive living the hard life?
- Find out where 'Charice' is getting those deep emotions when singing heartwarming songs that made her popular in Korea, United Kingdom, Italy, USA and the rest of the world. The episode will narrate the struggles of this young diva including the reason why she no longer uses the last name "Pempengco."
- Jay Bogayan in real life, Bugoy Drilon (Mark Bautista) grew up in an impoverished family in the town of Ocampo. Since childhood, he has dreamed of finishing his studies and performing on stage. His dreams were put on hold when his father became alcoholic and Bugoy had to work as a janitor in the university to finance his education. His life changed forever when he got the chance to audition for PDA 2, and the rest, they say, is history.
- All of us face trials and problems with varying degrees. Most of the time, our instinct tells us to give in and surrender without putting up a fight, living a life resigned to self-pity and loneliness. Of course, going the other way is the right thing to do, but the road to it proves to be harder than just simply giving in. But, there are individuals who prove to the world that they can remain victorious despite all odds, serving as an inspiration to other people as well. Giling (Joshua Dionisio) is one such person. At a young age, he was forced to leave school and work as a sakada in a sugar cane field, due to his father's orders. Everyday he toils under the sun in dangerous circumstances, and goes home to an abusive father who can't even put food on their table. To make things worse, his younger siblings Pering and Felix eventually die, fuelling his anger even more for his tyrant father, who, in a drunken rage, never fails to beat the hungry Giling and his siblings to a pulp. With this kind of life, it seems that the future is bleak for Giling. After all, not only is he a slave to a wealthy haciendero, he's also a slave to his abusive father as well. Is he doomed as a slave for life, or will he find a way to break away from it, and give a better future for his family?
- An impoverished family experiences another storm in their life when only son Jun acquires a rare brain illness. They had to find ways and beg money to help with his operation but they never forgot to turn to God. When the boy died the family's faith in God was tested but then he miraculously comes back to life.
- Richard (Derek Ramsay), a victim of sexual abuse by his own father who is a closet gay. Traumatized, he grows up with a burning desire to take revenge on his father and all gays in general. This is his distorted mission in life when he meets Billy (Coco Martin), a homosexual who is about to change every bad thing he believes in since his father raped him then left him behind. How will Richard deal with someone who reminds him of his father's sins? Will he find the meaning of true love once he gets to know Billy better?
- Known as the "Cinderella of Sasmuan," Mayor Lina Bagasina (Bea Alonzo) beat the odds to rise from being a humble housemaid to become the highest elected official in her town. How did she do it? And what lessons can her life story teach us all?
- Miriam (Lorna Tolentino) is a wife and mother who must endure the toughest of trials to keep her family together. Amidst the difficulty of providing for her children, Miriam will discover that her husband Jaime (Albert Martinez), is hooked on illegal drugs. She prays to God for strength to overcome the trials, but her faith will further be tested when she finds out that her son also falls prey to the same addiction.
- Two extraordinary characters who will discover the value of forgiveness and unconditional love through a series of seemingly laughable circumstances. Nelia (Assunta De Rossi), a physically-challenged woman whose main goal is to find a gorgeous guy who will fall for her despite her looks. The fact that even her own father doubts that she can find love makes it even more surprising for the people around her when she meets the handsome Arnel (James Blanco) who seems charmed by Nelia's genuinely nice attitude. Within a week's time, she quickly agrees to become his girlfriend despite his offer to get to know her better and properly court her. However, Arnel turns out to be a certified playboy, but Nelia has a strange way of dealing with his womanizing ways. Is it possible to be with someone who keeps on betraying your trust and still maintain a happy relationship?
- The true-to-life story of two mothers who will go to great lengths just to keep their ailing babies from dying. Judith (Carmina Villaroel) who's hard-pressed for money because of her baby's much-needed operation. Judith crosses paths with Aimee (Jodi Sta. Maria) at the hospital and discovers that she too is trying to raise enough money for her own baby's treatment. Despite their similar circumstances, Judith chooses to ruin their newfound friendship by stealing Aimee's hard-earned money. Should Judith get punished for a crime she is merely compelled to do in order to save her baby's life? But isn't it unfair for Aimee to be tricked that way since she is also suffering from the same predicament?
- Lolong (who'll later be known as Medal of Valor awardee Lt. Romualdo Rubi) (Jhong Hilario) who has chosen a career in the military despite his mother's and wife's protests. He will learn the hard way that such a path will cause him so much trouble and heartache.
- Hermie (Megan Young) is a campus beauty queen who has a secret passion to her escort John (Joross Gamboa. But John has a girlfriend and only endears Hermie as his sister. Hermie accidentally admits to John her feelings for him. Despite the lofty status in life of Hermie she does not mind supporting and helping John in his singing performances. Eventually Hermie grows tired of her feelings for John. A years has passed and she finds a new love. But what will Hermie do if John finally admits his love for her? Will she renounce her new love for John?
- Nadz (Coney Reyes), a woman who is still grieving her husband's death after two years. She joins her best friend in a program aimed at helping prisoners. Nadz meets Tonton (Rodjun Cruz), a young convict dealing with the worsening condition of the penitentiary. She figures that Tonton's case will get worse if he and other juvenile offenders will be mixed with older prisoners. Nadz decides to build Home without Bars, a facility that aims to give young prisoners a second shot at life. She cares for Tonton and the others like her own children. But amidst her efforts to do good, Nadz will also realize her love also has its limitations.
- Marie (Sarah Geronimo) came from a broken family. Her parents separated when her mother found out that her father had an affair with another woman. She, her mother Lucing (Cherry Pie Picache) and her elder brother, Marko (Jason Abalos) moved out from their house and started living in rented houses. Despite of it, she was living a comfortable life - she was enrolled in an exclusive school and had what she needed, not knowing that her mother was having a hard time at work already. They started moving to different places - from a fully furnished house, to more cramped studio-type apartments, dealing with annoying landladies and landlords, fraternity riots in the neighborhood, drug addicts, and were even threatened to be thrown out of the house many times. Her mother tried to shoulder the financial weight for the house rentals and their tuition. Soon, Marko moved out to live with their grandmother since he couldn't afford to live with them anymore. Marie was about to give up her studies when her mother pawned the only property they had - their house and lot in the province. Eventually, she was able to finish her studies. Amidst her family's struggle with finding home, Marie realized the greatest lesson life gave her - that a house is not a home if they would not stick together as a family.
- What if the life of your one true love is about to end? Toto (Billy Crawford), a pastor and a wedding singer, will come to know a blind girl called Nene (Nikki Gil in a wedding. Because of their love for each other, Toto and Nene will prove that love is greater than death.
- A coming-of-age tale of a circus boy who experiences love with its accompanying swirls, slows and stops just like the circus rides he is accustomed to.
- A story of age, generations of servitude, and the extent of a daughter's love for her family. Mae Ann (Erich Gonzales), a girl who was forced to stop schooling and had to work as a maid at a young age, while Bining (AiAi Delas Alas), her mother who comes in conflict with her daughter after tragedy struck their family.
- World War II had ended but to Filipino WWII veterans, who fought the war for the United States, is fighting another war. The story of three veterans on their lives, struggles, and pursuit of recognition in the US.
- A middle-aged woman trapped in an unhappy marriage suddenly divorced her husband and finds her long lost love from the past.
- A story of a so called 'NBSB (No Boyfriend Since Birth)' girl named Judy and her quest of finding love and its missing piece that she believes will complete her.
- Chen (Mika Dela Cruz) who has always been an avid fan of Philippine folklore because it was what her Lolo Uge (Ronaldo Valdez) instilled in her. But unlike other kids who eventually outgrow their fascination with mythical creatures such as dwarfs and fairies, Chen believes that they have the power to cure her mom's cancer. But when her mom suddenly dies, she begins to hate her grandfather for telling her the stories which she now sees as lies. Will she ever forgive Lolo Uge for encouraging her to hold on to her fantasies?
- Rhia Mae (Miles Ocampo), Leslie (Eliza Pineda), Apple (Jane Oineza), Lorimel (Kiray Celis), and Cherry (Angeli Gonzales) are about to discover the real meaning of friendship. Just like typical high school girls, they spend most of their time talking about either kikay stuff or cute boys in their class to the point that their parents become concerned about their dipping grades. Nothing can break them apart though since they have sworn to be the "best simple buddies forever" or BSBF. To prevent any conflict, their number one rule is that they won't keep any secret from each other. But then the barkada's common crush becomes attracted to Rhiamae who begins to meet him without telling her friends. What will happen once her BSBFs learn that she has broken their pact? Will they hate Rhiamae because she betrayed their trust or because she got the boy they'd all like to have for themselves?
- Santa (Zsa Zsa Padilla), a woman who stands to lose everything she values in life. First, she is forced to give up her dream of being a singer when she marries her boyfriend Pete (Raymond Lauchengco). Raising a family turns out to be a full-time job in itself, but singing remains her first love. When an opportunity for her to sing at funerals comes her way, Santa discovers that she can still use her talent to bring honor to the dead. Unfortunately, her family has never understood her passion for music and is uncomfortable with the fact she earns money as a wake singer. By the time she realizes how much her husband and her children detest her for being constantly away, her marriage is already on the rocks and her eldest son is addicted to drugs. Can she still save her family?
- Bebing (Maricar Reyes, a hunchback who has given up all hope of having a normal life. Though she is not totally embittered by her disability, she believes that no man would ever get attracted to her because of it. But then she meets Tonio (Carlo Aquino) who later falls in love with her. At first she denies that there's a mutual attraction between them, but she eventually gives in to her strong feelings for him. Unfortunately, the man's mother disapproves of his relationship with a hunchback like her. Can she take on the demeaning treatment and harsh criticisms all for the sake of love?
- A young teacher from the city is assigned to Gumapac Barrio School in a remote village in Tuy, Batangas.
- Jerome Concepcion (Gerald Anderson) who was diagnosed with Tourette Syndrome when he was already in his early 20s. Jerome bears a lot of emotional scars because he grew up being severely disciplined by his mom Criselda (Rio Locsin) who never understood his odd mannerisms and mood swings due to his illness. After his father passes away soon after being diagnosed with lung cancer, Jerome is left with no choice but to help his mom take care of his siblings. Is it too late for them to fix what went wrong between them? And how will Jerome deal with all the trials in his life when his illness always gets in the way?
- Will you be able to fall in love again, when you've been already hurt by it before? Two people are faced with this question as they both encounter terrible heartaches, and stumble upon each other, through a simple, yet life-changing action. Patty (Kaye Abad) and Lester (Diether Ocampo) may be worlds apart, and it may be literally so, as Lester is a seaman. However, their worlds intertwine through a chance phone call one night, and they discover that they both have something in common: they're both hurting from recent heartaches! Will this common denominator eventually equate with love?
- Bangka Part 1: Curing (Empress Schuck), a young girl who can't fulfill her dream of becoming a teacher during World War II. Curing is crushed when her parents ask her to stop schooling three months before her graduation because they have no money. Hoping for a better life, she decides to go to Manila with some of her townsfolk to search for opportunities for a better life. Is her fearlessness enough to conquer the dangers that she'll encounter along the way?
- In the concluding episode of Maalaala Mo Kaya's two-part special (Bangka Part 2), Curing (Chin Chin Gutierrez) begins her married life with Maning (Carlos Morales) who never understood her dogged pursuit of a better future for their kids. Curing who willingly takes on all kinds of odd jobs just to be able to send her children to a private school, much to her husband's displeasure. Time passes by but Curing (Gina Pareño) never stops believing that her efforts would eventually bear fruit. Curing finally becomes a successful businesswoman. As much as she takes pride in what she has accomplished in life, does Curing regret the difficult choices she had to make in the past?
- Tara Santelices (Karylle), a Political Science graduate of Ateneo who got shot in the head during a jeepney holdup on the eve of her birthday last August 6, 2008. Though she was comatose for almost a year, her dad (Albert Martinez) refused to take her off life support while her mom wanted her suffering to end. The Santelices family had a hard time accepting Tara's fate since not only was she a good daughter but she had touched a lot of people's lives with her advocacies. Proof of how well loved Tara was was the long line of visitors during her confinement in the hospital and her friends and acquaintances mounted various fund raising activities for her expensive hospital bills. How did Tara become such a great inspiration to many?
- Baby (Sharlene San Pedro), however has no reason to be happy about for she ends up alone in the big city after running away from her abusive mother. With no other place to go, she becomes attached to a poor blind beggar named Tatay Lando (Ramon Zamora), who reluctantly adopts the child after he realizes that she is all alone in this world. But as they become like the father and daughter they have each dreamed about, they both realize that a shadow hangs over their relationship - Tatay Lando is seriously ill. What kind of Christmas will this be for Tatay Lando and Baby? Would their made-up little family even survive the season?
- Lina (Dawn Zulueta), who runs away from home, thinking that she will be better off on her own. By the time she realizes her mistake, she could no longer find a way to keep in touch with her parents again. Left without a choice, she moves on with her life and starts to raise a family of her own. But as soon as her son Reyniel (Carl John Barrameda) is old enough to understand what she went through in the past, he begins to search for Lina's long-lost parents through the internet. How will Lina deal with her old wounds once Reyniel succeeds with his quest? Will she become a better person with them back in her life?
- Maria (Carmen Soo), an immigrant who leaves her homeland for a fresh start in Manila. The fulfillment that she gets from being a nurse would have been enough, but then her life takes a whole new meaning when she meets Rey (Luis Manzano) in a party. They soon find themselves deeply in love with each other to the point that Maria couldn't envision a life with Rey. What happens when he tells her that he plans to seek better opportunities abroad? Is it possible for them to maintain a long distance relationship or will they just let each other go?
- Eric (Zanjoe Marudo), a sincere and kind-hearted man who falls in love with a janitress named Aira (Valerie Concepcion). Just like any other persistent suitor, Eric is willing to do whatever it takes just to win his ladylove's heart. His efforts soon pay off and he and Aira get married. But then Aira gets romantically involved with a co-worker. What happens when Eric discovers her betrayal? Will they be able to save their marriage?
- With Ninoy behind bars, Cory became the father and mother of their five kids and at the same time became the source of inspiration and strength to her husband who experienced solitary confinement in Fort Bonifacio and Fort Magsaysay. After seven years and seven months, Ninoy was given a chance at new life, with his family in Boston. But after three years, Ninoy went back to the Philippines to pursue his dream of Philippine freedom while Cory and their children agreed to follow Ninoy after two weeks. But on August 21, 1983, a few minutes after his arrival, Ninoy was assassinated. Cory was devastated when she heard the news, but remained strong for their children. Along with millions of Filipinos, Cory mourned for the lost of Ninoy that led to People Power and Cory's rise to presidency.
- Both 17, Ninoy, an extrovert, met Cory, quiet and sheltered woman, at a bienvenida party and fell in love with her. He continued pursuing her, until one fateful accident on 1951, lead them to getting married. But Cory's dream of having a simple married life vanished when her husband decided to enter the world of politics. From being a mayor, Ninoy found his way to senate criticizing the Marcos regime, while Cory devoted her time and attention in raising their children and maintaining their home. The Aquino family was living a normal life, until the arrest of Ninoy and declaration of Martial Law on 1972.
- When Rox (Shaina Magdayao) meets Nathan (Jason Abalos), she doesn't expect to find an instant connection between them. But since she knows how much Ara really loves him, Rox tries to suppress her growing feelings for him. But then Nathan eventually confesses his love for Rox so they decide to keep their relationship secret. What will they do once Ara learns about their relationship? Will they fight for their love or will they sacrifice it for the sake of Ara's friendship?
- The Rene Cayateno Story.
- Bibot (Matt Evans), a typical bad boy who earns money from scavenging in the mountain of garbage in Payatas. With his notorious reputation, it's understandable why a decent girl like Len (Melissa Ricks) wouldn't give him the time of day. But when she sees how sincere and determined Bibot is to win her heart, she inevitably develops feelings for him. A happily-ever-after seems to be impossible, however, since Bibot still has to prove himself to Len's family. How will he convince them that he is worthy of their trust and respect?
- Being gang-raped is probably the worst thing a woman could ever experience in a lifetime. But for Katrina (Janice De Belen) who went through such a traumatic ordeal several times, she didn't let it stop her from moving on with her life and raising the children whose fathers she hates so much. She even worked hard to be a professional talent in show business just to provide a good home for them and yet she doesn't understand why her four sons couldn't appreciate any of her efforts. Not only do they disrespect her but they are also ashamed of her profession as a TV extra. Until such time that Katrina got fed up with all their complaints and disobedience to the point that she burst out her darkest secret just to knock some sense into them. With this turn of events, will Katrina be able to deal with being a single mom much better? What will truly set her free from the ghosts of her past?
- Brought together by their passion for dancing, Herbert (John Prats) and Elena (Maja Salvador) have been close friends since high school up to their college days. Elena has always been captivated by Herbert's talent and patience in helping others appreciate the art of dancing; while the latter simply enjoys having a beautiful and attentive pupil with whom he can practice his skills as an aspiring choreographer. Being around each other almost every day finally opens their eyes to the possibility of romance. The question is: are they better off as lovers or friends?
- The story of Nicole (Alwyn Uytingco), Samantha (Martin Del Rosario), and Jamaica (IC Mendoza) who became sampaguita vendors after their respective families disowned them for their sexual preferences. Despite their occasional misunderstandings, all three remain close friends and even make a pact to protect each other from the dangers of living in the streets. But when they get caught up in gangs for security, sex trafficking for survival, and drugs to escape reality, it seems that there's no going back to the simple but happy life that they used to have. How will they deal with the consequences of their actions?
- Sonny (Joem Bascon) and Laila (Precious Lara Quigaman) are a young couple who sought the help of an abortionist named Susan ('Jacklyn Jose'). As a manghihilot, Susan would frequently help women get rid of the baby in their womb. But because the act gives her so much guilt, Susan would light a candle and offer prayers to the souls on the unborn children she killed. However, when one of her patients ended up dead, Susan started seeing things she never imagined were possible. An apparition of a bloody woman would often follow her wherever she goes. In her dreams, the woman would appear carrying a child covered in blood. Who is this woman and what does she wants from Susan? How can Susan put a stop to this horrifying experience?
- For someone who grew up in the urban slums of Cavite, Efren Peñaflorida (Enchong Dee) rose above poverty to make something of himself. He acquired scholarship grants and financial assistance from several non-profit organizations because of his academic accomplishments. At the age of 16, he was able to establish the Dynamic Teen Company which provides alternative education by recreating school settings in unconventional locations such as cemeteries and dump sites.
- Maria (Gretchen Barretto), a widow who falls in love with a newly-transferred parochial priest Father Roy (Jomari Yllana). Despite her parents' disapproval, Maria ends up marrying the priest and raising a family with him. As they start their lives by moving to a new place, Maria thinks that they could finally live in peace but unexpected circumstances lead her to suffer the life of an outcast under the intense scrutiny of her community. Will she never be forgiven for marrying a priest? Is love enough to make things right in her life?
- Liwayway (or simply Rosie by day) (Cristine Reyes), a woman who's forced to work as a G.R.O. in a strip joint. Some may look down upon this kind of job, but all Liwayway cares about is to earn enough money for her to use in her search of her long-lost father. Along this journey, what various struggles will Liwayway face before she achieves such a simple dream? Will she find the one man who really means a lot to her, or will one big revelation suddenly push her on a different course?