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After being accused of assaulting a sick man, House is forced to take on his case. However, despite the fact that he has AIDS, it's clearly not what's killing him.

When an assistant district attorney acts in self-defense and kills a hit man in his home, the detectives attempt to find who ordered the hit on the ADA's life.

Goren has to interrogate his chameleon-like nemesis, Nicole Wallace, when she becomes a suspect in the slaying of a jewelry thief.

Detectives Goren and Eames investigate a copycat murder with telltale signs that it was committed by someone connected to an incarcerated serial killer.

The Detectives find themselves hunting for a person who cut off a man's genitals and left him to die.

When one difficulty after another hinder the prosecution of serial pedophile, Roy Barnett, desperate A.D.A. Alexandra Cabot oversteps the bounds of the law, risking both her job, and that of Benson and Stabler, to put this dangerous man behind bars.

A woman claiming to have been raped and left for dead commits suicide while waiting to be treated in the emergency room.

The investigation into a missing girl leads the detectives to a doctor of reproductive therapy, who runs shelters for troubled girls. When she is found at shelter, the doctor's sinister agenda is revealed.

When a young gymnast is found murdered, Detectives Benson and Stabler investigate both her demanding coach and a wealthy benefactor.

A senile elderly lady is found wandering inside in a home that she was familiar with as a child. Detectives realize that she has been suffering abuse, when cigarette burns are discovered all over her frail body. Following the trail from her greedy, neglectful son, to the expensive nursing home he pulled her out of, they discover the man they believe was abusing her. During the course of their investigation, however, Benson and Stabler stumble across an even more sinister criminal committing even more heinous, previously undetected crimes against the elderly.

Locke thinks he knows how to get the hatch open, and he and Boone venture inland. Jack is reluctant to help Sawyer get glasses.

The French woman arrives at the camp with a dire warning about a group of survivors known as the Others.

Jin attacks Michael for seemingly no reason; Jack wants to move the survivors over to the caves, although some people disagree.

Forty-eight survivors of an airline flight originating from Australia, bound for the U.S., which crash-lands onto an unknown island 1000 miles off course, struggle to figure out a way to survive while trying to find a way to be rescued.

Charlie begins a journey of withdrawal from drugs aided by Locke, whose true motive is a mystery. Jack is buried alive in a cave collapse.

Mr. Monk has to sit on a jury at a courthouse where he finds a dead body.

Fred is unsettled by the fact that Jackie turns to Dan, and not him, when she needs help from a man. Upset, convinced that Jackie has feeling for Dan, and half-drunk, Fred confronts Dan, takes a swing at him, and tells Jackie that maybe they shouldn't get married, but offers no explanation. Dan tells Roseanne, who tells Jackie what is really troubling Fred, and they both have a good laugh at the idea. Clearing the air paves the way for Fred and Jackie's wedding.

After proposing marriage to David, Darlene tells him that she is pregnant. They plan to wait to tell the family, but Roseanne smells the fear and jokingly guesses, correctly, that Darlene is pregnant. Dan is convinced that they are not ready to start a family, and is openly not happy for them at all. Roseanne, knowing that there is nothing she can do, feigns happiness and tries to give Darlene advice and support.

Trying to conceive another child, Roseanne puts Dan on a "lovemaking schedule," to no avail. Jackie discovers that she's pregnant from her one-night stand with Fred and hesitates about telling him. Roseanne has no problem spreading Jackie's good news to their mom and their friends, but is stopped before she can tell Fred. To relieve the pressure and disappointment, Dan and Roseanne decide to stop actually trying to get pregnant, and let nature take its course.

Darlene is fed up with David, who has been secretly living with her for months instead of his mother in Michigan as her parents believe, but feels guilty for constantly lying to them. A miserable Becky unfairly blames Roseanne for Mark walking out on her; tired of being blamed for the whole mess, Roseanne tries to get Mark to patch things up with Becky. Looking for him at his friend's apartment, she discovers the truth of David's whereabouts from Mark's confused roommate and heads to Chicago. She drags David home with her, but lies to Dan about why he's back.

After leaving Dan for not taking better care of himself, Roseanne goes on a "spiritual odyssey", imagining herself and Dan as Ann and Donald from "That Girl", Jeannie and Major Nelson from "I Dream of Jeannie", and Mary and Lou from "The Mary Tylor Moore Show". The family tries console Dan, and encourage Roseanne to reconcile with her heart-broken husband. Jackie discovers that they won the Illinois State Lottery worth 108 million dollars.

Roseanne and Dan clash over what will be donated to a charity drive. Dan has trouble letting go of his stuff, so he plots ways to keep it. Darlene is worried about a bad grade on her report card getting her into trouble, so she plots to conceal the truth from her parents. Jackie is upset with Booker for nearly standing her up... again.

Roseanne's mother, Beverly, visits for the weekend, much to the dismay of the family. Roseanne tricks Jackie into coming over to help keep her from being alone with her mother. While confessing youthful transgressions to their Mom for fun, Jackie discovers that her parents always thought she had potential to make something out of herself; while Roseanne discovers that they always knew that she would "just" be an ordinary housewife and mother. Roseanne finds this revelation hurtful, and wonders if she treats her own daughters that differently.

The Conners are selected to be a "Nielsen Family." Roseanne, who is going through a nesting period in her pregnancy, insists that the family watch only educational-type programming to prove to the Nielsen people that they are not white trash. After Dan breaks the couch, Roseanne accepts a hand-me-down couch from her mother, but soon regrets it. Jackie and Fred make a life-altering decision.

Part 1 of 2: D.J. is busted at school for having obscene reading material. Dan meets with the principal, but dreads it, because he is certain that the reading material D.J. brought to school is one of his raunchy magazines. He soon discovers that the reading material is far more twisted; begging the question of where D.J. got it, and leaving him speechless by the answer. Roseanne and Dan discover that Jackie has been keeping a dark secret, and each of them try to help her by dealing with it in their own, unique way.