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- When a dozen people die in a cinema fire, Connor is in charge of the investigation. Sam Ryan is coming back to Cambridge.
- Sam Ryan takes on a gangland murder case to help builder Brian McNally, whom she believes to be innocent.
- The team is called out to Northern Ireland to investigate the bodies of two men killed by paramilitaries twenty years ago. For Sam, it is a case that is soon to turn personal.
- In a suspected terrorist attack on a London hotel a government minister is killed. As Sam and the team investigate the case, old friends and government officials soon muddy the water.
- Questions about a celebrated pathologist's accuracy in past cases leads to several exhumations; Sam Ryan is assigned to reexamine the remains. One particularly brutal murder conviction depends on the time of death being precise. Two crucial witnesses are found: one on her deathbed, anxious to get something off her chest, and the other dead behind a remodeled wall.
- The team investigates the derailment of a train caused by someone leaving Maj. Mark Wiltshire's Land Rover on the tracks. The army is suspected but Wiltshire was in the officers mess at the time. The team have yet to identify the 21st victim, or determine if that person was on the train or in the car. Working with a survivor's group, they try to re-create where everyone was seated just prior to the crash occurring. When one of the survivors commits suicide, the crash claims its 22nd victim.
- When a boat carrying illegal passengers is found crashed in the Thames, the team investigate.
- The team follows the trail of the people traffickers, and has to find any remaining survivors before a highly contagious disease breaks.
- The team is called to a drive-by shooting outside a London nightclub. They arrive to a scene of carnage with several people dead, or dying.
- The police may have a serial killer on their hands when they locate a second body in a site where the first victim was found several months before. The body was trussed up in the same way and had an identical burn mark on his back. There is no apparent link between the first victim, student Michael Haughty, and the second Jason Villers, a probationer at the police college. While the police find evidence that may solve the Otty case, they have nothing on the Villers murder. In a separate case, Harry is approached by the wife of an old university friend who asks him to perform a post-mortem on her husband who died in a fall. Harry finds that his old friend was injecting himself regularly. Leo's family is visiting for a few days but he's constantly being called into work.
- Tensions are running high in the 'leaderless' team as Leo and Harry clash over an investigation into an outbreak of breathing difficulties among children on the South Coast.
- Sam Ryan is under great stress when she learns that she may have a tumor. As a result, she starts to question her judgment when she misses a possible explanation in determining the time of death in the case of Lloyd Dupen's wife, an apparent suicide. She's not convinced however that everything is above board and agrees to undertake a second autopsy at the request of the dead woman's mother. She's also asked by Bishop Craig to perform an autopsy on the remains of Sister Constance, a beatified nun who died forty years ago and is under consideration for canonization. The results of the autopsy will have an impact on the religious order as well as many of those in the community who see the commercial advantages of having a local saint.
- Sam comes under intense scrutiny during an official inquiry into the deaths of two brothers while they were in prison. Her findings are soon challenged by her colleague, Leo Dalton, who is brought in to perform a second autopsy. Meanwhile, a series of murders that are taking place cast suspicion on a recently released ex-convict. He served years in prison after being convicted of killing his wife; the evidence against him was given by Sam during one of her very first cases. During his time in prison, however, he continued to deny his guilt. Sam begins to believe that someone is stalking her, while the police have trouble locating the ex-convict.
- The team is shocked when Leo Dalton's wife and daughter are killed when a fancy sports car careens out of control and smashes into a café. The police are puzzled by the cause of the crash but believe the driver may have been involved in a identity theft ring when they find several several passports and ID cards in the vehicle. Meanwhile, Nikki must perform urgent autopsies on two bodies found floating in the river. When she finds fingerprint evidence linking one of the bodies to the car accident, it becomes apparent that the two cases are linked and the police may have been less than forthcoming about their investigation.
- After a helicopter sends out a mayday and disappears in a storm en route to provide support to an off-shore oil rig, Sam is called upon to participate on the rescue team in case it turns into a recovery team.
- The police investigate an apparent break-in that results in the death of Derek Irons, his wife and youngest daughter. Two older children survived the attack but one is in serious condition and in a coma. Irons was a ruthless businessman who targeted his rivals' customers resulting in regular confrontations. Irons was stabbed but his wife and daughter were shot. Sam is reunited with an old friend from Northern Ireland, Det. Supt. Tony Ashton who is the senior investigative officer on the case. Harry assists the police with the death of an old woman who is believed to have fallen down a staircase. His post-mortem reveals evidence that is not consistent with a fall.
- The team investigates two deaths, the first a suicide where someone jumped to their death and the second where a paranoid schizophrenic dressed as a vicar goes on a rampage stabbing innocent bystanders. Their suspicions are aroused when they learn that both men were receiving treatment at the same clinic, January House. Leo assists the police in their investigation of a building society employee who is forcibly taken from his house and subsequently found dead in his own car. Harry is asked to perform an autopsy and provide a second opinion in the death of a young woman. The death was ruled a suicide, but the mother refuses to accept the verdict.
- Harry is called out to a death at a racecourse. A jockey was killed when his horse pulled up and fell, crushing him to death.
- A John Doe is found months after his death; an attractive female agent for a championship athlete is believed to have jumped to her death from a rooftop. Forensic pathologists must sort out time and methods of death.
- When a decomposed body is found hidden in the wall of an old factory building, Sam Ryan concludes he was murdered. He is eventually identified by his ex-girlfriend Selina Thomson as Marcus Saul, who had simply disappeared one day some seven years earlier. There has also been a break-in on campus and drugs have been stolen. The Dean asks Leo Dalton to speak to some of the students on the issue, but he's not quite sure what he can do.
- Sam Ryan assists the police in the investigation of a multi-vehicle collision that results in the death of 11 people. She is joined by two new colleagues: Dr. Leo Dalton, an experienced pathologist from Sheffield and Dr. Harry Cunningham. As they try to determine the causes of the accident, they find a severed arm that does not belong to any of the victims. They also have to deal with DCI Carol Deacon whose role in the investigation is not quite clear to them. Sam and Leo have somewhat different approaches to their job, particularly in how they deal with the police. Harry performs his first autopsy on a child.
- Harry investigates the death of a woman who drowned in a backyard pool. She was apparently struck on the side of the head and her husband claims that her expensive necklace is missing. Leo and Nikki investigate the death of Lucie Philips, a kidnap victim who was taken a week previously. The girl's father tried to pay the ransom but the money was never collected leading the police to believe that the kidnappers may have had other motives. They also investigate the murder of a pizza deliveryman that has similarities with the Philips crime scene. A third murder leads the police to suspect that they may be seeing the work of a serial killer. Nikki's grandmother dies bringing her into contact with her estranged father.
- When twin brothers Jake and Henry Davies are found dead in their home, the police initially suspect robbery as the elderly gentlemen were known to keep large sums of cash in the house. The autopsy reveals murder however and Sam determines that skin grafts both men have on their arms may have been a crude form of plastic surgery meant to cover tattoos of concentration camp numbers. Thinking they are now dealing with a hate crime, the police focus on Carl Martin, a known race-hater. What they have however is a case of someone seeking revenge for the atrocities committed long ago.
- When the naked body of a young woman is found in the snow at a Norwegian ski resort, Sam Ryan is asked to represent the Townsend family whose daughter Ruth disappeared there several weeks before. The autopsy however reveals that it is in fact the body of Louise Hutton who had vanished there some 15 years previously. When Ruth's body is subsequently found, it appears both girls were strangled in a similar fashion. The police focus their enquiries on Ruth's boyfriend and on Henry Hutton, Louise's uncle while Sam seeks the advice of a university colleague and tries to draw a profile of the serial killer.
- Harry investigates a case of hit and run where the victim was a 16 year old boy from the nearby housing estate. Working with Sgt. Susan Fenn, they attempt learn if this was an accident or intentional. Harry takes quite a liking to Susan and is shocked by a sudden turn of event. Leo examines a death resulting from a house fire where the lady of the house died. He is puzzled at why she was unable to leave and the police immediately suspect the husband, who was in a nearby park with the children, of murder. Nikki looks into the case of a young woman who collapses at her hen night. She had recently had minor surgery and was taking pain killers, but there is surprising information to be found about her background.