"You get a car! You get a car! You get a car! Everybody gets a car!!!" Also known as the Great Pontiac Giveaway of 2005.
When she interviewed Michael Jackson at Neverland Ranch in 1993.
In 1988, when she toted a Radio Flyer wagon filled with 67 pounds of fat to symbolize the weight she lost.
Origins Ginger Souffle Whipped Body Cream and refrigerators that cost more than the average family's car -- these are but two of Oprah's favorite things, which change every year.
So overwhelming is Tom Cruise's love for Katie Holmes that in 2005, he treated The Oprah's couch as if it were a Moonbounce.
Her 1996 tiff with the beef industry when, in reaction to outbreaks of mad cow disease, she declared she was done with beef.
The 2006 Oprah road trip with BFF Gayle King.
Let's talk about poop with Dr. Oz, in 2005.
Ripping James Frey into a million little pieces in 2006 when it came to light that his memoir, an Oprah Book Club selection, was a fake.
Oprah hosts the entire Osmond family in 2007.
Oprah promotes "The Secret" in 2007.
Oprah's two-day election special in 2008.
Oprah chats with Sarah Palin in 2009.
Mackenzie Phillips drops the bomb about her alleged incestous relationship with her father John Phillips on Oprah in 2009.
Author Cormac McCarthy (The Road) grants Oprah his first ever on-camera interview at the Santa Fe Institute in 2007.
When actress Felicity Huffman realized her "wildest dream" and performed as Tina Turner's back-up singer in 2005.
Oprah gets Liberace's final interview, in 1986.