4 June 2014 2:55 PM, PDT | PEOPLE.com | See recent PEOPLE.com news »

For Giuliana and Bill Rancic, trying to grow their family has been an uphill battle. Now, it seems, they have one more try. After enduring one fertility setback after another, including a miscarriage in 2010 and Giuliana's bout with breast cancer in 2011, which was discovered while she underwent in vitro treatments, "These last few years have been tough," Giuliana, 39, tells People in this week's issue. A break in the clouds came when they welcomed son Duke via their surrogate Delphine in August 2012. And in January, when they learned Delphine was pregnant with their second child, "Things were finally looking up, »

- Janine Rayford Rubenstein

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