The 61-year-old - who made a return to the ITV show for its tenth series last year - said that although she loves the show, she has to put family and Us commitments first.
Asked if she would consider filling the one remaining spot on this year's panel, Osbourne told Loose Women: "No, no, no, you can't go back again. No.
"Love the show, it's become a part of British culture, everybody loves it, you can't help but get pulled into it but no, it's too much."
She added that juggling her commitments in the Us and UK proved too much last year: "I'd lose my job in America because they let me out for one season. I'd wake up in hotel rooms and not know where I was. Also I've got a family so I can't do it. »
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