No longer will we see politicians quaking in their boots, producers being slammed live on TV and awkward chats with rappers.
To mark the end of an era from quite possibly Britain's greatest news broadcaster of the last two decades, Digital Spy has rounded up just some of the classic moments of Paxo on Newsnight.
Possibly the sign of things to come in terms of Newsnight incorporating surprising guests and skits (see Cookie Monster and 'Thriller'). Paxman took part in a rather bizarre interview with Dizzee Rascal following Barack Obama's presidential victory in 2008. When asking Dizzee he believed in political parties in Britain, the rapper replied: "Yeah, they exist, I believe in them. But I don't know if I care," adding: "If you believe, you can achieve, innit." The awkward silences after Dizzee's points are also classic.