The Doctor Who actor directs and stars in the sci-fi action thriller, which also features Ian Somerhalder.
It centres around Ryan Reeve (Clarke), a former soldier who wakes up as a prisoner in the back of a van, not knowing where he is.
He goes on the run, uncovering secrets from his own past and a mind control plot that could change the world forever.
Brian Cox, Alexis Knapp and Luke Hemsworth also feature in the movie.
Clarke previously directed 184.108.40.206. and Adulthood.
The Anomaly is yet to reveal its release date.