The comic actor will portray radar developer Robert Watson Watt in the one-off film Castles in the Sky.
The film will centre around the Scotsman's flight to invent the detection system with a group of British scientists.
Breaking Bad's Laura Fraser will play Izzard's wife Margaret, while other cast members will include Alex Jennings (The Queen), Tim McInnerny (Blackadder) as Winston Churchill, David Hayman (Trial And Retribution) and Julian Rhind-Tutt (Green Wing).
Izzard said of the project: "I feel very privileged to be playing the role of Robert Watson-Watt. Hopefully our production will allow him, along with Arnold 'Skip' Wilkins and their team, to finally take their places in the pantheon of British greats of World War II, as the inventors of radar."
Elsewhere, BBC Two has also commissioned a new five-part series titled Human Universe, presented by Professor Brian Cox.