The news spread after they were spotted together during a dinner date at Sushi restaurant Matsuhisa in Beverly Hills, reports femalefirst.co.uk.
Theron is set to star in MacFarlane's latest film "A Million Ways to Die in the West", and the two met to discuss the film.
"(They) def aren't dating. They are just friends. Charlize is single," said a source.
The actress's last known relationship was with Irish actor Stuart Townsend. It lasted nine years.
- Ketali Mehta
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