The Oz the Great and Powerful actress has been consistently rumoured for the role of Ana Steele in El James's record-breaking erotic novel.
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When asked by Mario Lopez on Extra whether she was interested in the appearing in the film, she initially said "no".
Kunis immediately corrected herself by adding: "I'm not disinterested."
Numerous rumours have surrounded the coveted roles of Steele and Christian Grey for the adaptation, including Shailene Woodley, Emma Watson, Katie Cassidy, Emma Roberts, Alexandra Daddario, Krysten Ritter, Henry Cavill, James Deen and Chace Crawford.
"There are times when you just want to do something fun and different, because you're going to have a good time doing it," Kunis previously said when asked about the role by The Sun.
Kelly Marcel is working on the screenplay for 50 Shades of Grey,