Reed recently caused controversy by describing the actress as a "female hippo" and "tractor-sized" in his review for her new film Identity Thief.
He told Wor-am in New York that his words were "what sold tickets", helping Identity Thief grab $36.6 million at the box office in its opening weekend.
He said: "I object to using health issues like obesity as comedy talking points. That's what this girl does, this Melissa.
"I have too many friends that have died of obesity-related illnesses, heart problems and diabetes... I don't find this to be the subject of a lot of humour."
He added: "Don't make me a villain, [McCarthy] is crying all the way to the bank."
He also said that McCarthy has remained "completely classy" for staying silent on the incident.
In his original review, Reed had written: »
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