The Les Misérables actress has entered negotiations for the Oscars host's latest live action movie A Million Ways to Die in the West, according to The Hollywood Reporter.
Seyfried would appear alongside Charlize Theron, assuming that deals are succesfully concluded for both.
A Million Ways to Die in the West features a meek farmer who backs out of a gunfight, breaking up with his girlfriend as a consequence.
He befriends the wife of an outlaw when she offers to teach him how to shoot, falling for her just as her husband reappears on the scene.
MacFarlane is planning to direct and star in the film, which is tipped to enter production in May.
Watch Amanda Seyfried talking »
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