8 February 2013 1:11 PM, PST | E! Online | See recent E! Online news »

Another day, another lead actress leaving a TV show. Wait, no, that never ever happens! But Christina Applegate is indeed leaving NBC's Up All Night. "It's been a great experience working on Up All Night," Applegate said via statement. "But the show has taken a different creative direction and I decided it was best for me to move on to other endeavors. Working with Lorne Michaels has been a dream come true and I am grateful he brought me into his TV family. I will miss the cast, producers and crew, and wish them the best always." The news is particularly shocking given that Applegate makes up one-half of the show's core couple, along with Will Arnett, and the entire series has »

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