17 October 2012 6:41 PM, PDT | TVGuide - Breaking News | See recent TVGuide - Breaking News news »

Sure, Mark Sloan and Lexie Grey died, and Arizona had her leg amputated. But what has been most painful for some Grey's Anatomy fans this season is the agonizing distance between Cristina (Sandra Oh) and Owen (Kevin McKidd).

After the plane crash, Cristina hightailed it out of Seattle, willing to deal with the harsh winter of Minnesota to get as far away from her old stomping grounds as possible. Does her move signal the end of C/O as we know it? "I think they really are destined to be together," McKidd tells TVGuide.com.

Grey's Anatomy Sneak Peeks: April's back! Cristina's miserable!

Let's all take a moment to exhale. Below, McKidd dishes on what's in store for the troubled lovers this season, including Owen's big move. Plus: What are the repercussions of the plane crash? Get the scoop:

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- Natalie Abrams

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