The School of Rock star will be among the card sharks competing for big bucks at the All-In to Win for Hope event next month at the Commerce Casino in California.
Black will be joined by a slew of other stars, among them High School Musical's Bart Johnson, former Saved by the Bell star Dennis Haskins and actress Camryn Manheim.
Proceeds from the event will be donated to the Renal Support Network, which benefits those affected by chronic kidney disease, and Love Across The Ocean, a non-profit organisation which helps refugees from all over the world start a new life.
Event chairman Dale Wade Davis says, "We are excited to have Jack Black participate in our second annual celebrity poker tournament. On behalf of our tournament partner, Love Across The Ocean, we look forward to an afternoon full of entertainment and are honoured to have Jack help us raise awareness about chronic kidney disease and the importance of organ donation, as well as the plight of refugee families."