- Bobby Cannavale, who plays his father on Nurse Jackie (2009), is Jake's real-life father (with ex-wife/actress Jenny Lumet).
- Jake's great-grandmother was Lena Horne and his grandfather was Sidney Lumet.
- Two days before his first acting audition, for a role in Nurse Jackie (2009), he dyed his hair green. The gimmick worked and he got the part.
- After his father Bobby Cannavale, his maternal grandfather Sidney Lumet and two of his maternal great-grandparents Baruch Lumet and Lena Horne, he is the fourth generation of his family to perform in a Broadway play.
- With his blood ties to Bobby Cannavale, Lena Horne and the Sidney Lumet family, Jake is that rare fourth-generation member of an American show-business clan. And his polyglot ethnicity includes Cuban, northern European, Italian, Ashkenazi Jewish, Senegalese and Native American roots. Also from his great-grandmother Lena Horne's side, he is very likely a descendant of South Carolina political scion John C. Calhoun.
- Older half-brother of Rocco Cannavale and Rafa Cannavale.
- As of spring 2013, Jake was a high school junior who also sang in a heavy-metal band.
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