- (November 2002) Performs "Jesus is Magic" show she also wrote, in an engagement at the Canon Theatre, Beverly Hills, California, USA.
- (November 30, 2003) Publication of her article, "Free Horowitz: Winona Ryder Can Eat My Hairy Ass" for "Vice Magazine's" The Heroes Issue (#V10N10).
- (March 2006) Release of the Hee Haw (1969) inspired music video for "Rise Up With Fists" by Jenny Lewis with The Watson Twins, featuring appearances by Sarah Silverman, James Tamborello, and Morgan Nagler.
- (September 25, 2008) Release of her video "Sarah Silverman and The Great Schlep," in support of the 2008 presidential campaign of then Senator Barack Obama.
- (January 31, 2008) Release/Premiere of her song/video, "I'm F***ing Matt Damon" on Jimmy Kimmel Live! (2003). The song/video became an immediate Internet sensation. In July 2008, the song received a Creative Arts Primetime Emmy nomination for Outstanding Original Music and Lyrics, and then winning at The 60th Annual Primetime Emmy Awards on Sunday, September 21, 2008.
- (April 2014 - July 2014) TV commercial, "It Takes Place in Ancient Cleveland," with Sarah Silverman and voiceover by Mark Gessner, for Orbit Gum.
- (2016) Music video for Maroon 5: "Don't Wanna Know"