- Separated from Danny DeVito in October 2012. However, in March 2013, it was reported that they had reconciled. The couple later separated again for a second time in March 2017 on amicable terms. Although the two no longer lived together, Perlman said she had no intent of filing for divorce from DeVito. In late March 2018, Radar Online reported that they had again reconciled and were planning on renewing their wedding vows.
- Her father Philip Perlman was in the TV show Cheers (1982) as Phil, a bar patron.
- Along with Ted Danson and George Wendt, she is one of only three actors to appear in all 273 episodes of Cheers (1982).
- She has played the same character (Carla Tortelli) in five different television series: Cheers (1982), St. Elsewhere (1982), The Tortellis (1987), The Simpsons (1989) and Frasier (1993).
- Was nominated for an Emmy 10 times out of 11 years during her tenure on Cheers (1982).
- No relation to Ron Perlman.
- She met her husband Danny DeVito when she was a recurring actor on "Taxi." Although the characters didn't wind up together at the end, Danny and Rhea did get married in real life.
- Was Mike Myers' first choice for the role of Frau Farbissina in the Austin Powers film series, but she had just finished filming two back to back movies the previous year and turned down the role to take a small break from working. Comedienne Mindy Sterling was then cast in the role instead. Perlman has since gone on to say that Frau is the role she regrets passing on the most in her career.
- She starred in only one movie, Matilda (1996), with her husband Danny DeVito, where they played Matilda's parents. However before they were married, Rhea appeared in five episodes of Taxi (1978) as Louie's girlfriend Zena.
- Close friend of Lucy Liu.
- Older sister of producer-writer Heide Perlman.
- Mother, with estranged husband Danny DeVito, of three children: two daughters, Lucy Chet DeVito (Lucy DeVito; b. March 11, 1983) and Grace Fan DeVito (Gracie DeVito; b. March 25, 1985), and one son, Jacob Daniel DeVito (Jake DeVito; b. October 30, 1987).
- Her christian name is traditionally pronounced "Ray", but largely since she's female, she always prefers the "Ree-ah" pronunciation. (Perlman herself has stated that her parents were unaware of that pronunciation fact, at the time they named her).
- Majored in drama at Hunter College (NYC).
- Appeared with Richard Kind and Marilu Henner in Charles Busch's play "The Tale of The Allergist's Wife" at NY's Barrymore Theater. (June 2002)
- Cousin of Randall Miller.
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