- Suffers from a speech condition called "Spasmodic Dysphonia" causing him difficulty articulating words. The rare disorder afflicts about one in 100,000, and Kennedy first noticed his voice change at age 43.
- Son of Robert F. Kennedy and Ethel Kennedy.
- Has 4 children with deceased wife Mary Richardson: John Conor Richardson Kennedy (born 1994), Kyra LeMoyne Kennedy (born 1995), William Finbar "Finn" Kennedy (born 1997), and Aidan Caohman Vieques Kennedy (born 2001).
- Is a financial supporter of the Food Allergy Initiative.
- On April 16, 2003, appeared on "48 Hours Investigates" in support of his cousin Michael Skakel, who had been convicted of the 1975 murder of Martha Moxley.
- Grandson of Joseph P. Kennedy and Rose Kennedy.
- Has 2 children with ex-wife Emily Black: Robert Francis "Bobby" Kennedy III (born 1984) and Kathleen Alexandra "Kick" Kennedy (born 1988).
- Brother of Kathleen Kennedy Townsend, Joseph Kennedy, Kerry Kennedy, Michael LeMoyne Kennedy, Maxwell Kennedy, and Rory Kennedy.
- Husband of Cheryl Hines.
- Spent the summer of 1973 in Africa with Roger Ailes while they were both making a wildlife documentary titled The Last Frontier (1974).
- Grandfather of Zoe Victoria Kennedy, and Bobby Kennedy.
- Step-father of Catherine Rose Young.
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