Graduated from Northwestern University in 1990 with a BS in Theater.
D'Arcy is his middle name and his dad's brother, artist John d'Arcy James', middle name. Everyone called him d'Arcy. He added d'Arcy when he joined Actors Equity (there was already an actor named Brian James). For a while he was Brian d. James, but they wouldn't let that happen so instead of changing his name he used his full name.
Has a younger brother Andrew and a younger sister Kate who is acting in Chicago. Older sister, Anne, is on the Speech and Theatre faculty at New Trier High School.
His father, a lawyer, died in 1990 at the age of 50. His mother Mary sells children's books from her own company.
Was nominated for Broadway's Tony Award as Best Actor (Featured Role - Musical) for "Sweet Smell of Success."
Nominated for the 2009 Tony Award for Best Performance for a Leading Actor in a Musical for Musical "Shrek - The Musical".
On Broadway as James Dodd in "Time Stands Still", a new play by Donald Margulies directed by Danie Sullivan. With Eric Bogosian, Laura Linney, Alicia Silverstone [February 2010]
In rehearsals for "Shrek the Musical" where he will be playing Shrek. [August 2008]
His father was of English and Irish descent. His mother is of Irish ancestry.
His maternal grandfather, Harry Kelly, was Governor of Michigan, from 1943 to 1947.