- Sued her Martin (1992) co-star Martin Lawrence for sexual harassment. She abruptly left the show during its last season, and her character's disappearance was explained in the show's storyline as having left Detroit to run one of the L.A. offices.
- Tisha suffers from pulmonary (lung) sarcoidosis. Sarcoidosis is an inflammatory disease of unknown origin that can affect any organ and/or the central nervous system. It can present as an acute or chronic illness. She has stated that her lung involvement is well managed.
- A member of Diva Simply Singing, a group which raises funds for minority AIDS projects.
- Her son, Xen, has autism.
- Says she named her son, Xen, with an X, because as she and husband Duane Martin were driving to an ultrasound they were listening to rapper Xzibit, and later in the ultrasound they saw that the baby was in the womb making Xzibit's signature sign with his arms crossed in an X.
- Good friends with Vivica A. Fox and Tichina Arnold.
- Her mother, Mona Campbell, is her manager.
- Graduated from Newark Arts High School in Newark, New Jersey.
- Works frequently with Tichina Arnold.
- [February 22, 2018] Tisha announced on her Twitter account that she and her estranged husband Duane have filed for divorce after 27 years together.
- Released a music album in the 1990s, featuring her hit single "Push".
- Has 2 sons: Xen Waheed Martin (b. August 8, 2001) & Ezekiel Czar Martin (b. September 8, 2009) with ex-husband, Duane Martin.
- Oldest of 4 children (including her brother, Jermaine Campbell).
- Daughter of Mona Campbell and Clifton Campbell.
- In What's Love Got to Do with It (2009), she sings the French song "C'est si bon" which was written in 1947 by Henri Betti (music) and André Hornez (lyrics).
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