Ellen Pompeo at an event for Moonlight Mile (2002)

Amy Brenneman and Ellen Pompeo at an event for Moonlight Mile (2002)

Mark Duplass, Ellen Pompeo, and Imogen Faith Reid in Good American Family (2025)

James Pickens Jr., Ellen Pompeo, and Chandra Wilson in Grey's Anatomy (2005)

Patrick Dempsey, Katherine Heigl, Justin Chambers, Sandra Oh, James Pickens Jr., Ellen Pompeo, Chandra Wilson, and T.R. Knight in Grey's Anatomy (2005)

Vince Vaughn, Will Ferrell, Luke Wilson, Elisha Cuthbert, Ellen Pompeo, and Perrey Reeves in Old School (2003)

Justin Chambers, James Pickens Jr., Ellen Pompeo, and Chandra Wilson in Grey's Anatomy (2005)

Debra Messing and Ellen Pompeo in Debra Messing & Ellen Pompeo (2025)

Ellen Pompeo in Good American Family (2025)

Mark Duplass and Ellen Pompeo in Good American Family (2025)

Ellen Pompeo and Imogen Reid in Good American Family (2025)

Ellen Pompeo and Mike Colter in Ellen Pompeo/Mike Colter/Loud Luxury/Bryce Vine (2019)

David Schwimmer and Ellen Pompeo in Friends (1994)

Ellen Pompeo and Josh Radnor in Grey's Anatomy (2005)

Ellen Pompeo and Jaicy Elliot in Grey's Anatomy (2005)

Kevin McKidd and Ellen Pompeo in Grey's Anatomy (2005)

Ellen Pompeo and Camilla Luddington in Grey's Anatomy (2005)

Sandra Oh and Ellen Pompeo in Grey's Anatomy (2005)

Sandra Oh, Ellen Pompeo, and Sara Ramirez in Grey's Anatomy (2005)

Patrick Dempsey, Justin Chambers, Kevin McKidd, James Pickens Jr., Ellen Pompeo, Sara Ramirez, and Chandra Wilson in Grey's Anatomy (2005)

Patrick Dempsey, Jessica Capshaw, Justin Chambers, Kevin McKidd, Sandra Oh, James Pickens Jr., Ellen Pompeo, Sara Ramirez, Jesse Williams, and Chandra Wilson in Grey's Anatomy (2005)

Patrick Dempsey, Katherine Heigl, Jessica Capshaw, Justin Chambers, Kevin McKidd, Sandra Oh, James Pickens Jr., Ellen Pompeo, and Chandra Wilson in Grey's Anatomy (2005)

Patrick Dempsey, Katherine Heigl, Jessica Capshaw, Justin Chambers, Sandra Oh, James Pickens Jr., Ellen Pompeo, Jesse Williams, and Chandra Wilson in Grey's Anatomy (2005)

Patrick Dempsey, Katherine Heigl, Jessica Capshaw, Justin Chambers, Kevin McKidd, Sandra Oh, James Pickens Jr., Ellen Pompeo, Sara Ramirez, Jesse Williams, and Chandra Wilson in Grey's Anatomy (2005)

William Baldwin and Ellen Pompeo in Art Heist (2004)

Patrick Dempsey, Katherine Heigl, Justin Chambers, Sandra Oh, James Pickens Jr., Ellen Pompeo, Isaiah Washington, Chandra Wilson, and T.R. Knight in Grey's Anatomy (2005)

Patrick Dempsey, Katherine Heigl, Kate Walsh, Justin Chambers, Eric Dane, Sandra Oh, James Pickens Jr., Ellen Pompeo, Sara Ramirez, Isaiah Washington, Chandra Wilson, and T.R. Knight in Grey's Anatomy (2005)