Biggest Departures from TV Shows

Spoiler warning, some departures are recent from this season. A lot of shows have been killing regulars off on Fall finales.
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1.
“ They had the last season without the main character. His friends still hung-out in his basement. While a new creep named Randy was added and even hit on Donna......in Eric's basement. ” - jwoehr
 
2.
“ Spoiler: was hit by a car and Stewie can't change time to save him since he destroyed his time machine. But cheer up, a new annoying dog took his place. ” - jwoehr
 
4.
“ I think Ashton Kutcher only agreed to do the show if his character got called well hung and hot every 2 seconds. Now they added a lesbian daughter of Charlie who acts like him. Yes, the show has gone down hill since Charlie left. ” - jwoehr
 
6.
Ziva David
NCIS (2003 TV Series), Cote de Pablo
 
7.
Mark Greene
ER (1994 TV Series), Anthony Edwards
 
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13.
Diane Chambers
Cheers (1982 TV Series), Shelley Long
 
14.
Lana Lang
Smallville (2001 TV Series), Kristin Kreuk
“ She was an overused character and the writers couldn't even let her depart the show without super powers. ” - jwoehr
 
15.
“ No, Robert Patrick didn't kill the X-Files, David Duchovny killed the X-Files by leaving. Yeah, he made appearances without being a regular but big whoop. ” - jwoehr
 
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18.
Charlie Pace
Lost (2004 TV Series), Dominic Monaghan
 
19.
Caitlin Todd
NCIS (2003 TV Series), Sasha Alexander
 
20.
Michael Vaughn
Alias (2001 TV Series), Michael Vartan
“ The actor left due to it being hard to work with Jennifer Garner after she left him for Ben Afflick. He came back for the last 2 or 3 episodes anyway. ” - jwoehr
 
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Kevin Tran
Supernatural (2005 TV Series), Osric Chau
“ This one is the most recent. So if you didn't see the spoiler, not my fault lol. ” - jwoehr
 
31.
“ Just saw this one when catching up on Sons of Anarchy. ” - jwoehr
 
32.
“ He's dead but makes a small appearance about once a season. ” - jwoehr
 
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36.
“ Gemma needs to die. Wish she did instead. ” - jwoehr
 
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