The Best Series Stars

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1.
Jeremy Piven
Actor, Entourage
Born in Manhattan and raised in Evanston, Illinois, he is an alumnus of the Piven Theatre Workshop founded by his parents (Byrne Piven and Joyce Hiller Piven) and a one time Chicago stage actor.
 
2.
Jason Segel
Multi-talented Jason Jordan Segel was born in Los Angeles, California, where he was raised by his parents, Jillian (Jordan), a homemaker, and Alvin Segel, a lawyer. His mother is of English, Scottish, and Irish ancestry, and his father is of Ashkenazi Jewish descent. He was educated at St. Matthew's Parish School in Pacific Palisades...
 
3.
Jared Padalecki
Jared Padalecki was born in San Antonio, Texas, to Sherri (Kammer), a teacher of English, and Gerald Padalecki, a tax accountant. He is of Polish (father) and German, English, Scottish, and French (mother) descent. Jared started to take acting lessons when he was 12. Then, he won the "Claim to Fame" Contest in 1999 and got to appear on the Teen Choice awards...
 
4.
Alyson Hannigan
Alyson Hannigan was born in Washington, D.C., to Emilie (Posner), a real estate agent, and Al Hannigan, a truck driver. She began her acting career in Atlanta at the young age of 4 in commercials sponsoring such companies as McDonald's, Six Flags, and Oreos. She is a seasoned television actress veteran...
 
5.
Jim Parsons
Having grown up in Houston, and its northern suburb of Spring, he made his first stage appearance in a school play at the age of 6. Parsons then went on to study theater at the University of Houston. From there he won a place on a two-year Masters course in classical theater at the University of San Diego/The Old Globe Theater, graduating in 2001...
 
6.
Neil Patrick Harris
Neil Patrick Harris was born in Albuquerque, New Mexico, on June 15, 1973. His parents, Sheila Gail (Scott) and Ronald Gene Harris, were lawyers and ran a restaurant. He grew up in Ruidoso, New Mexico, a small town 120 miles south of Albuquerque, where he first took up acting in the fourth grade. While tagging along with his older brother of 3 years...
 
7.
Kaley Cuoco
Kaley Christine Cuoco was born in Camarillo, California, to Layne Ann (Wingate) and Gary Carmine Cuoco, a realtor. She is of Italian (father) and German and English (mother) descent. A model and commercial actress from the age of 6, Cuoco's first major role was in the TV movie Quicksand: No Escape with Donald Sutherland and Tim Matheson...
 
8.
Emily Deschanel
Actress, Bones
Emily Erin Deschanel (born October 11, 1976) is an American actress and producer. She is best known for starring in the Fox crime procedural comedy-drama series Bones as Dr. Temperance Brennan since 2005. Deschanel was born in Los Angeles, California, to cinematographer and director Caleb Deschanel and actress Mary Jo Deschanel (née Weir)...
 
9.
Jensen Ackles
Jensen Ross Ackles, better known as simply Jensen Ackles, was born on March 1, 1978, in Dallas, Texas, to Donna Joan (Shaffer) and actor Alan Ackles. He has English, German, and Scottish ancestry. Jensen grew up in Richardson, Texas, together with his older brother, Joshua, and a younger sister...
 
10.
Bryan Cranston
Bryan Lee Cranston was born on March 7, 1956 in Hollywood, California, to Audrey Peggy Sell, a radio actress, and Joe Cranston (Joseph Louis Cranston), an actor and former amateur boxer. His maternal grandparents were German, and his father was of Austrian, German, Irish and Jewish ancestry. He was raised partly by his grandparents...
 
11.
Jane Leeves
Actress, Frasier
Jane Leeves has made her mark in the entertainment world, acting in television, theater and film over the past 20 years. Leeves stars in the Emmy® Award-winning TV Land series, Hot in Cleveland, which in 2011 was nominated for a Screen Actors Guild Award® for Outstanding Performance by an Ensemble in a Comedy Series...
 
12.
Alex O'Loughlin
The Australian actor Alex O'Loughlin was born in August 1976. Alex started out his film career in 2004, when he starred in Oyster Farmer as Jack Flange. The following year, he returned to the big screen as Michael Carter in Feed, a movie that he also co-produced and helped write. Also released that year was a movie titled Man-Thing, in which Alex played Deputy Eric Fraser...
 
13.
Stana Katic
Actress, Castle
Stana Katic just completed 8 seasons as Kate Beckett on Castle. The ABC hit series brought in over 10 million viewers weekly and is in the top five syndicated series in Spain, France, the UK, Italy, and Germany. In 2015, Stana completed two feature films - The Rendezvous directed by Amin Matalqa and Sister Cities based on the play by Colette Freedman...
 
14.
John C. McGinley
Actor, Scrubs
John C. McGinley's path to stardom is a story that reads like a classic Hollywood script. While an understudy in New York in the Circle-In-The-Square production of John Patrick Shanley's "Danny and the Deep Blue Sea," he was spotted by director Oliver Stone and soon after was cast in "Platoon," the...
 
15.
Simon Baker
Simon Baker was first recognized in 1992, when he received Australia's prestigious Logie award for Most Popular New Talent. Upon relocating to Los Angeles with his family, Baker was immediately cast in the Academy Award winning film L.A. Confidential.
 
16.
Nathan Fillion
Actor, Castle
Nathan Fillion was born on 27 March 1971 in Edmonton, Alberta, Canada. He is the younger son of Cookie (Early) and Bob Fillion, both retired English teachers. He has an older brother, Jeff. In Canada, he attended Holy Trinity Catholic High School, Concordia University College of Alberta and University of Alberta...
 
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18.
David Boreanaz
Actor, Bones
David was born in Buffalo, New York and grew up in Philadelphia, Pennsylvania. He is the son of Patti, a travel agent, and weatherman Dave Roberts (Boreanaz). His father is of Italian descent and his mother is of half Slovak ancestry. At the age of seven he decide to be an actor, which eventually led him to study cinema and photography at Ithaca College in New York...
 
19.
A.J. Cook
Born in Oshawa, Ontario, Canada, to Michael and Sandra Cook, Andrea Joy Cook began acting at the age of 17. She has appeared in nearly a dozen films and several TV shows before the age of 25. Before taking up acting, she was a dancer, having started dancing competitively at age 4 in the styles of tap...
 
20.
Charlie Sheen
Charlie Sheen was born Carlos Irwin Estévez on September 3, 1965, in New York City. His father, actor Martin Sheen (born Ramon Antonio Gerard Estevez), was at the time just breaking into the business, with performances on Broadway. His mother, Janet Sheen (née Templeton), was a former New York art student who had met Charlie's father right after he had moved to Manhattan...
 
21.
Jennifer Love Hewitt
Jennifer Love Hewitt was born in Waco, Texas, to Patricia Mae (Shipp), a speech-language pathologist, and Herbert Daniel Hewitt, a medical technician. She has English, Scottish, and German ancestry. She got her first name from her older brother Todd Daniel Hewitt (b. November 8, 1970), who picked the name after a little blonde girl he then had a crush on...
 
22.
Cote de Pablo
Actress, NCIS
Cote de Pablo was born in Santiago, Chile, but was raised in Miami, Florida. She attended Arvida Middle School in Miami and then Carnegie Mellon University. She graduated in 2000 after studying music theater. Whilst at Carnegie Mellon she appeared in several theater productions, including "Indiscretions"...
 
23.
Kelsey Grammer
Actor, Cheers
A six-time Emmy Award winner, Kelsey Grammer was born in Saint Thomas, U.S. Virgin Islands, to Sally (Cranmer), a singer, and Frank Allen Grammer, Jr., a musician and restaurateur. He was raised in New Jersey and Florida. Grammer was drawn to the works of William Shakespeare and spent two years at the prestigious Juilliard School...
 
24.
Michael Weatherly
Actor, NCIS
Michael Manning Weatherly, Jr. was born on July 8, 1968 in New York City, to Patricia Ruth (Hetherington) and Michael Manning Weatherly, Sr. Raised in Fairfield, CT, he left college to pursue a career in acting. He also had a great passion for music, and played in a band while pursuing his acting career...
 
25.
James Roday
Actor, Psych
James David Rodríguez was born on April 4, 1976. He is the son of Jim Rodríguez, who worked for Boardwalk Auto Group. Roday was born in San Antonio. He attended Taft High School. He studied theater at New York University's Experimental Theatre Wing, where he earned a bachelor's degree in fine arts. He has acted in several theatrical productions...
 
27.
Shemar Moore
Shemar Franklin Moore (born April 20, 1970) is an American actor and former fashion model. His notable roles are that of Malcolm Winters on The Young and the Restless from 1994 to 2005, Derek Morgan on CBS's Criminal Minds from 2005 to 2016, and as the third permanent host of Soul Train from 1999 to 2003.
 
28.
Robin Tunney
Actress, The Mentalist
Robin Tunney studied acting at the Chicago Academy for the Arts, spending her summer performing in such plays as "Bus Stop" and "Agnes of God". She moved to Los Angeles at the age of eighteen and shortly landed roles in such television shows as Life Goes On, Class of '96 (recurring), Law & Order...
 
29.
Timothy Olyphant
Actor, Justified
From Timothy Olyphant's first screen appearances, such as his two-minute bit in The First Wives Club, to "Nicko", whose presence at times dwarfed the island in A Perfect Getaway, he has been a force to be reckoned with. Born in Hawaii, Timothy David Olyphant was raised in Modesto, California. He is the son of Katherine Lyon (Gideon) and John Vernon Bevan Olyphant...
 
30.
Ted Danson
Actor, Cheers
Ted Danson is well known for his role as Sam Malone in the television series Cheers. During the show's 11-year run, he was nominated nine times for an Emmy Award as Outstanding Lead Actor in a Comedy Series and won twice, in 1990 and 1993. The role also earned him a Golden Globe Award for Best Actor in a Comedy Series in 1989 and 1990...
 
31.
Hugh Laurie
Actor, House M.D.
Hugh was born in Oxford, England on June 11, 1959, to Patricia (Laidlaw) and William George Ranald Mundell "Ran" Laurie, a doctor, both of Scottish descent. He was educated at Eton and Cambridge. Son of an Olympic gold medalist in the sport, he rowed for the England youth team (1977) and for Cambridge (1980)...
 
33.
Sarah Chalke
Actress, Scrubs
Sarah Chalke was born on 27 August 1976 in Ottawa, Ontario, Canada. Her parents are Angie Chalke and Doug Chalke. She is the middle child, having one older sister, Natasha Chalke, and one younger, Piper Chalke. Sarah made her acting debut in a made-for-TV movie, City Boy. In 1993, after her first film...
 
34.
Scott Caan
Scott Caan is the son of tough guy actor James Caan. While it is obvious that he admires tough method actors like Marlon Brando and Sean Penn, Scott also has a strong egalitarian streak, evidenced by his reasoning for baring his body in films. He is quoted as saying that originally only the women in the scene were to be nude, but that he felt it really sexist, so he stripped too...
 
35.
Calista Flockhart
Actress, Ally McBeal
Calista Kay Flockhart was born 11 November, 1964 in Freeport, Illinois. Her mother, Kay (Honohan), was a school teacher, and her father, Ronald Flockhart, worked for Kraft Foods Inc. She has Irish, Scottish, German, and English ancestry. Calista was named after two of her great-grandmothers, who both had the middle name "Calista"...
 
36.
Mark Harmon
Actor, NCIS
Thomas Mark Harmon was born in Burbank, California on September 2, 1951 to football player and broadcaster Tom Harmon and actress Elyse Knox (née Kornbrath). Harmon played college football and found success as one of TV's hunkiest actors. While many of his roles have relied on good looks, Harmon was impressive as the suave doctor on St. Elsewhere who contracted AIDS...
 
37.
David Hyde Pierce
Actor, Frasier
David Hyde Pierce was born on 3 April 1959 in Saratoga Springs, New York, USA. He is the youngest child of George and Laura Pierce (both deceased) and has two older sisters (Barbara and Nancy) and an older brother (Thomas). As a child, he was very interested in music (particularly piano) and regularly played the organ at his local church (Bethesda Episcopal Church)...
 
38.
Matt LeBlanc
Actor, Friends
Matt LeBlanc was born on 25 July 1967 in Newton, Massachussetts. His mother, Patricia, is of Italian origin, and worked as an office manager, and his father, Paul LeBlanc, who was from a French-Canadian family, was a mechanic. After graduating from high school, he spent some time as a photo model in Florida before moving to New York where he took drama classes...
 
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