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- CreatorRon LeavittMichael G. MoyeStarsEd O'NeillChristina ApplegateKatey SagalAl is the quintessential working class dad. Peggy, his wife, always wants more from him. With their children, they go through the highs and lows of ordinary life.
- CreatorSteven LevitanChristopher LloydStarsEd O'NeillSofía VergaraJulie BowenThree different, but related, families face trials and tribulations in their own uniquely comedic ways.
- StarsChris O'DowdRichard AyoadeKatherine ParkinsonThe comedic misadventures of Roy, Moss and their grifting supervisor Jen, a rag-tag team of IT support workers at a large corporation headed by a hotheaded yuppie.
- CreatorChuck LorreBill PradyStarsJohnny GaleckiJim ParsonsKaley CuocoA woman who moves into an apartment across the hall from two brilliant but socially awkward physicists shows them how little they know about life outside of the laboratory.
- CreatorKevin BiegelBill LawrenceStarsCourteney CoxChrista MillerBusy PhilippsFollows the escapades and relationships of a group of neighbors living in Gulfhaven, Florida.
- CreatorDavid KohanMax MutchnickStarsEric McCormackDebra MessingMegan MullallyGay lawyer Will and straight interior designer Grace share a New York City apartment. Their best friends are gleeful and proud gay Jack and charismatic, filthy-rich, amoral socialite Karen.
- CreatorTracy GambleStarsKatey SagalKaley CuocoAmy DavidsonThe Hennessy clan -- mother Cate, daughters Bridget and Kerry, and son Rory -- look to one another for guidance and support after the death of Paul, the family patriarch. Cate's parents lend a hand.
- CreatorDavid CraneMarta KauffmanStarsJennifer AnistonCourteney CoxLisa KudrowFollows the personal and professional lives of six twenty to thirty year-old friends living in the Manhattan borough of New York City.
- CreatorDanny JacobsonPaul ReiserPeter TolanStarsPaul ReiserHelen HuntJohn PankowMad About You centers on the trials and tribulations of a married couple living in New York.
- CreatorDavid AngellPeter CaseyDavid LeeStarsKelsey GrammerJane LeevesDavid Hyde PierceDr. Frasier Crane moves back to his hometown of Seattle, where he lives with his father and works as a radio psychiatrist.
- CreatorMark BrazillBonnie TurnerTerry TurnerStarsTopher GraceLaura PreponMila KunisA comedy revolving around a group of teenage friends, their mishaps, and their coming of age, set in 1970s Wisconsin.
- CreatorCarter BaysCraig ThomasStarsJosh RadnorJason SegelCobie SmuldersA father recounts to his children - through a series of flashbacks - the journey he and his four best friends took leading up to him meeting their mother.
- CreatorPaul SimmsStarsDavid FoleyStephen RootAndy DickThe workplace sitcom "NewsRadio" explores the office politics and interpersonal relationships among the staff of WNYX NewsRadio, New York's #2 news radio station.
- CreatorDavid E. KelleyStarsJames SpaderWilliam ShatnerCandice BergenBoston Legal is a spin-off of the long-running David E. Kelley series The Practice (1997), following the exploits of former Practice character Alan Shore (James Spader) at the legal firm of Crane, Poole, and Schmidt.
- CreatorGary David GoldbergStarsMichael J. FoxMichael GrossMeredith BaxterChronicles liberal ex-hippies Steven and Elyse Keaton, their conservative son Alex, daughters Mallory and Jennifer, and later, youngest child Andrew.
- CreatorBill LawrenceStarsZach BraffDonald FaisonSarah ChalkeIn the unreal world of Sacred Heart Hospital, intern John "J.D." Dorian learns the ways of medicine, friendship and life.
- CreatorJames BurrowsGlen CharlesLes CharlesStarsTed DansonRhea PerlmanJohn RatzenbergerThe regulars of the Boston bar "Cheers" share their experiences and lives with each other while drinking or working at the bar where everybody knows your name.
- CreatorDanielle AlexandraMichael JacobsStarsPaul ReiserGreg EviganStaci KeananWhen Marcy Bradford dies, she leaves her teenage daughter Nicole in the custody of two ex-boyfriends: straight-laced, formal Michael and wild artist Joey.
- CreatorCarmen FinestraDavid McFadzeanMatt WilliamsStarsTim AllenEarl HindmanTaran Noah SmithThe daily trials and tribulations of Tim "The Tool Man" Taylor, a television show host raising three mischievous boys with help from his loyal co-host, loving wife, and eccentric neighbor.
- CreatorDavid W. DuclonStarsSoleil Moon FryeGeorge GaynesCherie JohnsonYoung Punky Brewster is abandoned with her dog, Brandon, in a supermarket. When she befriends Henry Warnimont, her new family life begins.
- CreatorJon BeckermanRob BurnettStarsTom CavanaghJulie BowenJosh RandallA separated, fired NYC lawyer returns to his hometown in Ohio, meets old high school friends and cute crush, buys a bowling alley and opens a law office in it.