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- DirectorDeran SarafianStarsHugh LaurieLisa EdelsteinOmar EppsA police officer in critical condition has bizarre symptoms, and Dr. Foreman finds himself in an unpleasant situation.
- DirectorDeran SarafianStarsHugh LaurieLisa EdelsteinOmar EppsHouse tries radical procedures to save Foreman's life; Foreman's father visits.
- DirectorFred GerberStarsHugh LaurieLisa EdelsteinOmar EppsOn a class field trip, a teacher discovers that her six-year-old student, Ian, is bleeding profusely. Dr. House thinks Ian has the same unknown disease that killed an elderly patient of his years ago.
- DirectorJohn F. ShowalterStarsHugh LaurieLisa EdelsteinOmar EppsHouse takes on a teenage faith healer, Wilson desperately wants into a poker game, and tensions escalate between Cameron and Foreman.
- DirectorFélix Enríquez AlcaláStarsHugh LaurieLisa EdelsteinOmar Epps6 months after a teenage girl crushes her chest in a car accident and receives a heart transplant she goes into anaphylactic shock in her clean bedroom after her boyfriend almost kisses her and discovers something on her arm.
- DirectorDavid SemelStarsHugh LaurieLisa EdelsteinOmar EppsChaos ensues after Chase's negligence leads to the death of a female patient. Now, after an inquiry from the hospital board, and a subpoena from the patient's brother, it's up to Stacey to protect Chase's career, as well as House's.
- DirectorGloria MuzioStarsHugh LaurieLisa EdelsteinOmar EppsAfter being accused of assaulting a sick man, House is forced to take on his case. However, despite the fact that he has AIDS, it's clearly not what's killing him.
- DirectorFred GerberStarsHugh LaurieLisa EdelsteinOmar EppsStar bicycle racer collapses, and the team must come up with a diagnosis after the patient admits to blood doping. House and Stacy continue sparring with each other. Clinic Case: Flight attendant poisons himself with gum.
- DirectorGreg YaitanesStarsHugh LaurieLisa EdelsteinOmar EppsThe team takes care of a student with inexplicable electrical shocks, and House's parents visit.
- DirectorPeter O'FallonStarsHugh LaurieLisa EdelsteinOmar EppsA doctor campaigns against the epidemic of TB in Africa, possibly at the risk of his own life.
- DirectorDaniel AttiasStarsHugh LaurieLisa EdelsteinOmar EppsCuddy joins the team after her handyman falls off of her roof and begins to develop bizarre symptoms. Clinic Cases: African American man who objects to "minority meds."
- DirectorDeran SarafianStarsHugh LaurieLisa EdelsteinOmar EppsA very brave and mature 9-year-old girl has terminal cancer, but that is not what the problem seems to be.
- DirectorDaniel AttiasStarsHugh LaurieLisa EdelsteinOmar EppsHouse treats a patient on death row while Dr. Cameron avoids telling a patient she has a terminal illness.
- DirectorDeran SarafianStarsHugh LaurieLisa EdelsteinOmar EppsDuring a meningitis outbreak which overwhelms the clinic, House is drawn to a single patient: a 12-year-old competitive diver whose symptoms don't quite match everyone else's.
- DirectorDaniel AttiasStarsHugh LaurieLisa EdelsteinOmar EppsWhen the son of a man in a vegetative state starts going into a coma, the vegetative man is reawakened chemically by House, who hopes to get some clues to the son's problems.
- DirectorDaniel SackheimStarsHugh LaurieLisa EdelsteinOmar EppsA young man collapses at his job, and House makes a game of establishing the diagnosis until things turn critical, and Tritter increases the pressure on Wilson.
- DirectorDeran SarafianStarsHugh LaurieLisa EdelsteinOmar EppsWhile a little girl's life and limbs are in jeopardy, Tritter becomes more manipulative and House suffers withdrawal.
- DirectorTony ToStarsHugh LaurieLisa EdelsteinOmar EppsWilson presents the deal to House and then convinces Cuddy to back him up, meanwhile the team is flummoxed by a patient's condition and various members keep seeking out House for his opinion even though he may not be prepared to assist.
- DirectorMatt ShakmanStarsHugh LaurieLisa EdelsteinOmar EppsWhen a pregnant woman has a stroke, the team is at a loss after all tests reveal nothing, but when her organs start shutting down Cuddy takes over the case.
- DirectorDeran SarafianStarsHugh LaurieLisa EdelsteinOmar EppsA woman seeing her dead mother stumps the recruits, especially once she begins seeing a recent victim.
- DirectorDaniel SackheimStarsHugh LaurieLisa EdelsteinOmar EppsA dad kisses his wife and baby goodbye before leaving for work, pukes and returns to find his wife with seizure in the bathtub and the baby under water. Foreman is back but changed.
- DirectorDavid ShoreStarsHugh LaurieLisa EdelsteinOmar EppsAn old patient of House comes back and seeks revenge upon him in the form of gunshot.
- DirectorDeran SarafianStarsHugh LaurieLisa EdelsteinOmar EppsRichard, a husband and father living with brain cancer, drives his wheelchair into a pool at a family BBQ. Everyone but his son think that it was suicide from the pain but House will stop at nothing to figure out his true ailment.
- DirectorDeran SarafianStarsHugh LaurieLisa EdelsteinOmar EppsA woman collapses at an off-track betting parlor in front of House, and he must battle his new boss to find her diagnosis.
- CreatorDavid ShoreStarsHugh LaurieOmar EppsRobert Sean LeonardUsing a crack team of doctors and his wits, an antisocial maverick doctor specializing in diagnostic medicine does whatever it takes to solve puzzling cases that come his way.
- DirectorDeran SarafianStarsHugh LaurieLisa EdelsteinOmar EppsAn obese man in a coma presents treatment challenges, but finding out what's wrong with him may be the most challenging test of all. Elsewhere, Tritter ramps up his vendetta against House.
- DirectorJace AlexanderStarsHugh LaurieLisa EdelsteinOmar EppsWhen a famous writer is brought in with language difficulties, House must assist via phone while waiting for a delayed plane.
- DirectorBryan SingerStarsHugh LaurieLisa EdelsteinOmar EppsYoung kindergarten teacher Rebecca Adler collapses in her classroom after losing intelligible speech while teaching students.
- DirectorPeter O'FallonStarsHugh LaurieLisa EdelsteinOmar EppsThe team helps a high school boy (16) who has double vision and night terrors. (Clinic Cases: Unvaccinated baby, man with boil on leg.)
- DirectorBryan SingerStarsHugh LaurieLisa EdelsteinOmar EppsA college boy whose low blood pressure does not respond with IV fluids piques House's curiosity. Clinic Cases: A woman who had a cold last week, man with a sore throat, woman whose leg hurts after running 6 miles, a boy and his MP3 Player.
- DirectorNewton Thomas SigelStarsHugh LaurieLisa EdelsteinOmar EppsA nightmare scenario hits Princeton Plainsboro when babies in the maternity ward are hit by a potentially fatal epidemic. Clinic Cases: Woman with a parasite!
- DirectorWilliam DearStarsJohn LithgowMelinda DillonMargaret LangrickThe Henderson family adopt a friendly Sasquatch but have a hard time trying to keep the legend of 'Bigfoot' a secret.
- DirectorChris ColumbusStarsDaniel RadcliffeRupert GrintEmma WatsonAn orphaned boy enrolls in a school of wizardry, where he learns the truth about himself, his family and the terrible evil that haunts the magical world.