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- CreatorCarter BaysCraig ThomasStarsJosh RadnorJason SegelCobie SmuldersA father recounts to his children - through a series of flashbacks - the journey he and his four best friends took leading up to him meeting their mother.
- CreatorSteven LevitanStarsLaura San GiacomoEnrico ColantoniGeorge SegalHot-tempered journalist Maya got herself fired yet again. Unable to find a job anywhere else and facing eviction, she is forced to go work for Blush, her father's fashion magazine.
- CreatorKevin BiegelBill LawrenceStarsCourteney CoxChrista MillerBusy PhilippsFollows the escapades and relationships of a group of neighbors living in Gulfhaven, Florida.
- CreatorDavid CraneMarta KauffmanStarsJennifer AnistonCourteney CoxLisa KudrowFollows the personal and professional lives of six twenty to thirty year-old friends living in the Manhattan borough of New York City.
- CreatorRyan MurphyStarsDylan WalshJulian McMahonJoely RichardsonTwo plastic surgeons--one a dedicated family man and one an unscrupulous playboy--strive to maintain their business whilst having to work their way through numerous hardships ranging from personal to clients with criminal connections.
- CreatorLee AronsohnChuck LorreStarsJon CryerAshton KutcherAngus T. JonesA hedonistic jingle writer's free-wheeling life comes to an abrupt halt when his brother and 10-year-old nephew move into his beach-front house.
- CreatorRob LottersteinStarsMichael RapaportAnita BaroneKaylee DeFerParents struggle to raise their teens.
- CreatorJoss WhedonStarsSarah Michelle GellarNicholas BrendonAlyson HanniganA young woman, destined to slay vampires, demons and other infernal creatures, deals with her life fighting evil, with the help of her friends.
- CreatorMarc CherryStarsTeri HatcherFelicity HuffmanMarcia CrossSecrets and truths unfold through the lives of female friends in one suburban neighborhood after the mysterious suicide of a neighbor.
- CreatorMitchell HurwitzStarsJason BatemanMichael CeraPortia de RossiLevel-headed son Michael Bluth takes over family affairs after his father is imprisoned. But the rest of his spoiled, dysfunctional family are making his job unbearable.
- CreatorRon LeavittMichael G. MoyeStarsEd O'NeillChristina ApplegateKatey SagalAl is the quintessential working class dad. Peggy, his wife, always wants more from him. With their children, they go through the highs and lows of ordinary life.
- CreatorDarren StarStarsSarah Jessica ParkerKim CattrallKristin DavisFour female New Yorkers gossip about their sex lives (or lack thereof) and find new ways to deal with being a woman in the late 1990s.
- CreatorRob ThomasStarsKristen BellJason DohringEnrico ColantoniAfter her best friend is murdered, and her father is removed as county Sheriff, Veronica Mars dedicates her life to cracking the toughest mysteries in the affluent town of Neptune.
- CreatorTom HertzStarsPatrick WarburtonMegyn PriceOliver HudsonTwo couples and their single friend, all at different stages in their relationships, deal with the complications of dating, commitment, and marriage.
- CreatorJeff RakeDarren StarStarsAlicia SilverstoneLake BellDavid ConradA Los Angeles matrimonial attorney doubles as a high-end matchmaker although her own love life is less than perfect.
- CreatorBill LawrenceStarsZach BraffDonald FaisonSarah ChalkeIn the unreal world of Sacred Heart Hospital, intern John "J.D." Dorian learns the ways of medicine, friendship and life.
- CreatorCecelia AhernDonald ToddStarsChristina ApplegateJennifer EspositoKevin DunnA woman suffers from amnesia and is forced to find out who she really is.
- CreatorEileen HeislerDeAnn HelineStarsPatricia HeatonNeil FlynnCharlie McDermottThe daily mishaps of a married woman and her semi-dysfunctional family and their attempts to survive life in general in the town of Orson, Indiana.
- CreatorJonathan SchmockNell ScovellStarsMelissa Joan HartCaroline RheaBeth BroderickSabrina is a normal teenager, except for one thing - she's a witch. Guided by her aunts, who come from a long line of witches, and Salem, a mischievous warlock doing penance as a cat, Sabrina continually struggles to harness her powers.
- CreatorSuzanne MartinStarsValerie BertinelliJane LeevesWendie MalickThree middle-aged best friends from Los Angeles are flying to Paris when their plane makes an emergency landing in Cleveland. Realizing that all the norms from Los Angeles don't apply anymore, they decide to celebrate a city that values real women and stay where they're still considered hot.
- CreatorShana Goldberg-MeehanScott SilveriStarsMatt LeBlancPaulo CostanzoDrea de MatteoIn this spin-off of Friends (1994), Joey Tribbiani moves to Los Angeles to pursue his acting career.
- CreatorChuck LorreDottie Dartland ZicklinStarsJenna ElfmanThomas GibsonJoel MurrayA free-spirited yoga instructor finds true love in a conservative lawyer and they get married on the first date. Though they are polar opposites, he fulfills her need of stability and she fulfills his need of optimism.
- CreatorDanny JacobsonPaul ReiserPeter TolanStarsPaul ReiserHelen HuntJohn PankowMad About You centers on the trials and tribulations of a married couple living in New York.
- CreatorLinwood BoomerMichael GloubermanGary MurphyStarsFrankie MunizBryan CranstonJustin BerfieldA gifted young teen tries to survive life with his dimwitted, dysfunctional family.
- CreatorDale McRavenStarsBronson PinchotMark Linn-BakerMelanie WilsonA high-strung and cynical man's life is never the same when his naive but good-natured cousin comes to America to live with him.
- CreatorJames L. BrooksMatt GroeningSam SimonStarsDan CastellanetaNancy CartwrightHarry ShearerThe satiric adventures of a working-class family in the misfit city of Springfield.
- CreatorDavid LittMichael J. WeithornStarsKevin JamesLeah ReminiJerry StillerDeliveryman Doug Heffernan has a good life: He has a pretty wife (Carrie), a big television, and friends with which to watch it. Then Carrie's goofy, annoying father Arthur moves in with them.
- CreatorGregory Thomas GarciaStarsJason LeeEthan SupleeJaime PresslyA ne'er do well wins $100,000 in the lottery and decides to right all the wrongs from his past with his newfound realization!
- CreatorDoug EllinStarsKevin ConnollyAdrian GrenierKevin DillonFilm star, Vince Chase, navigates the vapid terrain of Los Angeles with a close circle of friends and his trusty agent.