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- As long as hearts exist inside people, there will always be those who suffer. And then something "strange" enters their mind and causes a strange disease to manifest itself in the body. The illness, which is called a "mystery disease" is unknown to most, but certainly exists. There is a doctor and apprentice who fights the disease, which modern medicine cannot cure. His name is Ramune. He acts freely all the time, is foul-mouthed, and doesn't even look like a doctor. However, once he is confronted with the mysterious disease, he is able to quickly uncover the root cause of his patients' deep-seated distress and cure them. And beyond that.
- Saenome are tasked with sealing spirits that possess objects and pose a threat to society. Known as tsukumogami, these spirits are generally non-violent, and saenome normally seal them after a simple verbal exchange. Traumatized by a previous deadly encounter with a malevolent spirit, Hyouma Kunato refuses to use peaceful methods and gets into physical confrontations with all tsukumogami that cross paths with him. Deeming this behavior unacceptable for a future clan leader, Hyouma's grandfather, Zouhei, proposes that he starts living with Botan Nagatsuki, a young woman whose family is composed of six tsukumogami-lest he be excommunicated. Determined to track down the spirit that took everything from him, Hyouma reluctantly accepts Zouhei's proposal. As unknown groups of evil spirits begin to jeopardize the balance between worlds, the young man must gain the trust of Botan and overcome his hatred for her mysterious family.