Nefertari first appears as the wife of Ramesses II in official scenes during the first year of Ramesses II. In the tomb of Nebwenenef, Nefertari is depicted behind her husband as he elevates Nebwenenef to the position of High Priests of Amun during a visit to Abydos. Nefertari also appears in a scene next to a year 1 stela. She is depicted shaking two sistra before Taweret, Thoth and Nut.
Nefertari is an important presence in the scenes from Luxor and Karnak. In a scene from Luxor, Nefertari appears leading the royal children. Another scene shows Nefertari at the Festival of the Mast of Amun-Min-Kamephis. The king and the queen are said to worship in the new temple and are shown overseeing the Erection of the Mast before Amen-Re attended by standard bearers. Nefertaris speech during this ceremony is recorded:
"Your beloved son, the Lord of Both Lands, Usermaatre Setepenre, has come to see you in your beautiful manifestation. He has erected for you the mast of the (pavilion)-framework. May you grant him eternity as King, and victory over those rebellious (against) His Majesty, L.P.H."
Nefertari appears as Ramesses IIs consort on many statues in both Luxor and Karnak. In Western Thebes, Nefertari is mentioned on a statuary group from Deir el-BAhari, a stela and blocks from Deir el-Medina.
The greatest honor was bestowed on Nefertari however in Abu Simbel. Nefertari is depicted in statue form at the great temple, but the small temple is dedicated to Nefertari and the goddess Hathor. The building project was started earlier in the reign of Ramesses II, and seems to have been inaugurated by ca year 25 of his reign (but not completed until ten years later).
Nefertaris prominence at court is further supported by cuneiform tablets from the Hittite city of Hattusas (today Boghazkoy, Turkey), containing Nefertari's correspondence with the king Hattusili III and his wife Pudukhepa. She is mentioned in the letters as Naptera. Nefertari is known to have sent gifts to Puduhepa:
The great Queen Naptera of the land of Egypt speaks thus: Speak to my sister Puduhepa, the Great Queen of the Hatti land. I, your sister, (also) be well!! May your country be well. Now, I have learned that you, my sister, have written to me asking after my health. ... You have written to me because of the good friendship and brotherly relationship between your brother, the king of Egypt, The Great and the Storm God will bring about peace, and he will make the brotherly relationship between the Egptian king, the Great King, and his brother, the Hatti King, the Great King, last for ever... See, I have sent you a gift, in order to greet you, my sister... for your neck (a necklace) of pure gold, composed of 12 bands and weighing 88 shekels, coloured linen maklalu-material, for one royal dress for the king... A total of 12 linen garments.
Nefertari is shown at the inaugural festivities at Abu Simbel in year 24. Her daughter Meritamen is depicted taking part in place of her mother in some of the scenes. Nefertari may well have been in failing health at this point. After her death she was buried in tomb QV66 in the Valley of the Queens.