Spider-Man made his first appearance in Amazing Fantasy #15, the last issue before cancellation. Due to his popularity, the web-spinning superhero got his own comic series not long after his introduction.
Spider-man is Peter Parker.
When he was in his final year of high school, Peter was touring the science lab of Columbia University. While there, an escaped spider fell upon Peter, biting him. Thus, the DNA strands of the spider were recombined with those of Peter, giving him the strength, speed, and agility of a spider.
Peter decided to use his newfound powers to become a wrestler. After the wrestling promoter refused to pay him the full prize purse, Peter left the wrestling arena. He saw a robber escaping with the box office proceeds from the event. Peter refused to stop him, thinking he was merely getting even with the promoter. However, when he was walking down the streets, he found out that his uncle Ben was shot by a carjacker who stole his car. Angry and bitter, Peter went out to confront the carjacker in his wrestling costume.
After an intense chase, he tracked down the carjacker to an abandoned warehouse with no lights. Peter soundly defeated him, but he wanted to see the face of the man responsable for the death of his uncle. Thus, he pushed him into the light of a window. The carjacker was the very same person that robbed the arena that same night. If Peter stopped him when he had the chance, his uncle would still be alive.
Ridden with guilt, Peter decided to use his powers to fight crime and help others in need. He learned "With Great Power, Comes Great Responsibility." Thus, he became Spider-Man.
Spider-Man's most noted power is his ability to crawl on nearly any surface. Along with this, he has super strength and agility. He has a "spider-sense" which warns him of danger, and can generate webbing from his wrists. Using web shooters and web cartridges he invented.
Like all superheroes, Spider-Man does have his enemies. His 'Rogues Gallery' is a large one, with characters such as Rhino, The Lizard, Electro, The Vulture, Scorpion, Mysterio and many others. However, unlike other superheroes, Spider-Man does not have just one archenemy, he has three! As The Green Goblin, Dr. Octopus and Venom have all established themselves, at various times, to be among the most iconic and recurring villains in Spider-Man's Rogue Gallery. These three have caused Spider-Man more personal pain than any others.