Le Chiffre is the main villain of the official 2006 James Bond film, Casino Royale, portrayed by Danish actor Mads Mikkelsen. Believed by MI6 to be Albanian and officially stateless, according to his file, Le Chiffre is a financier of international terrorism. M implies that Le Chiffre conspired with al-Qaeda in orchestrating 11 September 2001 attacks, or at least deliberately profiteered from them by short-selling large quantities of airline stocks prior to the attacks. In the video game version of Quantum of Solace, it is said that his birth name is "Jean Duran", in the MI6 mission briefings. A mathematical genius and a chess prodigy, his abilities enable him to earn large sums of money on games of chance and probabilities, and he likes to show off by playing poker. He suffers from haemolacria, which causes him to weep blood out of a damaged vessel in his left eye, and, as in Fleming's novel, dresses in immaculate black suits and uses a Salbutamol inhaler, here plated with platinum. To date he is the only main Bond villain to die before the film's final act.
Le Chiffre is contacted by Mr. White, a representative of an elite criminal organisation later revealed to be Quantum. White introduces Steven Obanno, a formidable leader of the Lord's Resistance Army in Uganda, to Le Chiffre, and arranges to bank several briefcases full of cash for Obanno. Le Chiffre invests the money along with his other creditors' money in the aircraft manufacturer SkyFleet. Though SkyFleet's shares have been skyrocketing, he plans to short the company by purchasing put options, and ordering the destruction of the company's new prototype airliner, set to make its first flight out of Miami International Airport. Bond intervenes and foils the plan, costing Le Chiffre $101.206 million.
In order to win the money back, Le Chiffre sets up and enters a high stakes Texas hold 'em tournament at Casino Royale in Montenegro in an attempt to recoup his losses before his clients find out that their money has been misappropriated. Bond is sent to make sure that Le Chiffre does not win back the money; the reasoning is that by bankrupting Le Chiffre, he'll be forced to turn to MI6 for asylum, in exchange for information on his creditors and employers.
During the tournament, an enraged Obanno and his lieutenant break into Le Chiffre's hotel room and threaten him and his girlfriend, Valenka. Le Chiffre does not object to the threatened amputation of Valenka's arm, and is granted one last chance to win their money back.
As Obanno leaves the room, his bodyguard spots Bond and hears Valenka's cries coming from Bond's earpiece. Bond kills the bodyguard by throwing him over a railing, then chokes Obanno to death after relieving Obanno of his machete. Rene Mathis arranges the blame to be placed on Le Chiffre's bodyguard Leo.
During the tense tournament, Le Chiffre initially outwits and bankrupts Bond, who cannot get additional funding from MI6 accountant Vesper Lynd, who has accompanied Bond to make sure the money is used properly. However, Felix Leiter, a CIA agent sent to participate in the game for the same reasons MI6 has planted Bond in the game, agrees to bankroll Bond, on the condition that CIA is allowed to take Le Chiffre in afterwards. Desperate, Le Chiffre has Valenka attempt to spike Bond's drink. Bond almost dies, but, thanks to an antitoxin kit in his car, a defibrillator, and Vesper's timely interference, he is revived at the last moment and returns to the game. During the final round, Le Chiffre's full house bests the hands of the two players preceding him, but loses to Bond's straight flush.
Enraged by his loss, Le Chiffre kidnaps Vesper, forcing Bond to give chase, and Bond is led straight into his trap. Le Chiffre leaves Vesper, bound at the feet and hands, in the middle of the road, and Bond is forced to swerve to avoid hitting her and crashes his car.
When Bond regains consciousness, he is stripped naked and bound to chair with the seat cut out. Le Chiffre proceeds to torture him by repeatedly whipping him in the testicles with the large knotted end of a roped carpet beater, trying to extract the password that will enable Le Chiffre to collect the tournament winnings. Bond refuses to give in and plays on Le Chiffre's fear that there will be retribution from the clients whose money he lost. Le Chiffre then states that if he is unable to retrieve the password then he will still kill both Bond and Vesper and opt for protection from MI6; Le Chiffre says that he wins either way. When Bond refuses to give in, Le Chiffre brandishes a knife and is about to castrate him when he hears gunshots from outside. Seconds later, Mr. White bursts into the room, holding a suppressed SIG Sauer P230. Le Chiffre pleads for his life, promising that he'll get the money, but it is to no avail; Mr. White responds coldly, "Money isn't as valuable to our organisation as knowing who to trust" and then fatally shoots Le Chiffre in the face.